色谱、光谱指纹图谱及燃烧热整合评价柏子养心丸质量  

Assessing Baizi Yangxin Pills Quality by Merging Chromatographic Fingerprints,Spectrum Fingerprints and Combustion Heat

作　　者：孙国祥[1] 殷瑞娟[1] 李晓稳[1] 

机构地区：[1]沈阳药科大学药学院,辽宁沈阳110016

出　　处：《中国医药工业杂志》2013年第8期789-795,共7页Chinese Journal of Pharmaceuticals

基　　金：国家基础科学人才培养基金资助(J1103606);国家自然科学基金重大研究计划课题(90612002)

摘　　要：建立柏子养心丸的高效液相指纹图谱、紫外指纹图谱、红外指纹图谱以及燃烧热谱,基于优势互补原则,用5种模型对上述分析方法进行整合,每种分析方法均用系统指纹定量法评价柏子养心丸质量。综合分析结果显示1批质量稍差(5级或以上),1批质量差异显著,其余批次质量较好(3级或以下)。色谱、光谱指纹图谱及燃烧热实现了对中药全化学成分(双键、三键和饱和键)的全面监测,为中药质量控制提出一种新思路。The HPLC fingerprints, ultraviolet spectrum fingerprints, infrared spectrum fingerprints and the combustion heat ofBaizi Yangxin Pills were developed. Based on the principle of complementary advantages, five models were integrated and the systematic qualified fingerprint method was used to evaluate the quality of the medicine. Finally, the results showed that one batch （the grade≥5） was worse. The quality grade of one batch was different in different analytical methods, and the others （the grade≤3） were better. All the chemical constituents were comprehensively monitored by merging the spectrum fingerprints, chromatograph fingerprints and combustion heat, which showed it could be a novel media for the quality control of traditional Chinese medicine.

关 键 词：柏子养心丸 高效液相色谱 紫外光谱 红外光谱 指纹图谱 燃烧热 多维指纹图谱整合 

分 类 号：TQ460.72[医药卫生—药物分析学]