米非司酮对孕激素受体的影响  

The effect of Ru486 to progesterone receptor in uterine leiomyomata and endometriosis interna

作　　者：孙景礼 骆永凤[1] 范丽环[1] 秦丽洁 

机构地区：[1]吉林长春市中心医院,长春130051 [2]吉林长春妇幼保健院

出　　处：《中国航天工业医药》2000年第2期8-11,共4页

摘　　要：目的 探讨米非司酮对子宫肌瘤与子宫腺肌症组织中孕激素受体的抑制作用.方法 采用多点法测定子宫肌瘤、子宫腺肌症及正常子宫肌层组织中孕激素受体含量,研究60例门诊患者,其中子宫肌瘤50例,全部为壁间肌瘤,子宫腺肌症10例.月经后3天开始每日口服米非司酮25mg,连续服用三个月.结果 子宫肌瘤体积于用药第4周开始下降,至12周明显下降,平均下降了48.6%(48.6%±8.7%),P<0.001,有显著性差异.子官腺肌症患者临床症状减轻或消失,子宫体积平均减少了17.6%,有显著性差异(P<0.05),服药3个月后追踪20例患者(18例子宫肌瘤,2例子宫腺肌症),子宫彩超检查显示子宫与子宫肌瘤体积无增大趋势.子宫肌瘤与子宫腺肌症患者子宫肌层组织内的孕激素受体含量高于正常的子宫肌层组织.结论 子宫肌瘤组织与子宫腺肌症患者子宫肌层组织内孕激素受体表达高于正常子宫肌层组织,米非司酮阻断孕激素作用,直接影响靶组织中孕激素受体的数量,使子宫肌瘤体积和子宫腺肌症患者子宫体积明显缩小,子宫腺肌症症状减轻或消失.ve To investigate the effect of Ru486 in inhibiting progestrone receptor(PR) levels inuterine leiomyomata and endometriosis interna .Methods Lowry's method is used to detect PR levels in uterineleiomyomata endometriosis interna and uterns. Sixty patients in policlinic(fifty ustrine leiomyomata and ten en-dometriosis interna women)were given Ru486, 50mg/day, for 3 months begining on day 3 of the menstrual cycle.Results Leiomyomata volume decreased after 4 weeks, 48. 6% (48. 6% ± 8. 7% )after 12 weeks (P < 0. 01). Clini-cal symptoms of endometriosis interna patients relieved or disappeared, and uterine volume decreased 17.6% (P< 0. 05). Twenty cases were followed up after 3 months, including eighteen cases of uterine leiomyomata and twocases of endometriosis interna. PR levels of uterine leiomyonata and endometriosis interna is higher than normaluterus. Conclusion PR levels of uterine leiomyomata and endometroisis interna are higher than normal uterus.Ru486 effect the number8(quantity )of PR in target tissue.

关 键 词：子宫肌瘤 子宫腺肌症 米非司酮 孕激素受体 

分 类 号：R969[医药卫生—药理学]