O-己酰化壳聚糖季铵盐的合成及其抗菌活性研究  

Synthesis and antibacterial activity of O-hexanoyl quaternary ammonium chitosan

作　　者：王朝[1] 辛梅华[1] 李明春[1] 林水森[1] 

机构地区：[1]华侨大学材料科学与工程学院,环境友好功能材料教育部工程中心,福建厦门361021

出　　处：《功能材料》2013年第15期2148-2151,共4页Journal of Functional Materials

基　　金：国家自然科学基金资助项目(20574024);科技部科技人员服务企业资助项目(2009GJC40030);福建省重点科技资助项目(2009H0030);福建省自然科学基金资助项目(2011J01312;2012J01396)

摘　　要：采用两步法合成N,N,N-三甲基壳聚糖季铵盐,再用己酰氯改性,得到N,N,N-三甲基-O-己酰化壳聚糖季铵盐(TMHC)。产物用1 H NMR、FT-IR和EA等进行表征。抗菌实验结果表明,酰化改性能有效提高壳聚糖季铵盐的抗菌活性,并且随着酰化度的提高抗菌活性增加;TMHC对革兰氏阳性菌S.au-reus的抗菌活性比革兰氏阴性菌E.coli强;另外,相同浓度(50mmol/L)金属离子对TMHC抗菌活性的抑制作用按以下顺序递减:Ba2+>Ca2+>Mg2+,而同一金属离子(Mg2+)对TMHC抗菌活性的抑制作用则随着离子浓度的增加而增加。O-methyl free N,N,N-trimethyl chitosan（TMC） was synthesized through two steps,then TMC and hexanoyl chloride were used to prepare N,N,N-trimethyl-O-hexanoyl-chitosan（TMHC）.The products were characterized by 1H NMR,FT-IR and EA.The results of antimicrobial test indicated that the antibacterial activity of TMHC was stronger than TMC by acylation modification,and increased with the degree of substitution increased.TMHC showed stronger antibacterial activity against S.aureus than against E.coli.In addition,the same concentration（50mmol/L） of divalent cations reduced the antibacterial activity of TMHC in the following order：Ba2＋ Ca2＋Mg2＋.And the antibacterial activity inhibition of TMHC at the same metal ion（Mg2＋） condition reduced with the increasing ion concentration.

关 键 词：壳聚糖 季铵盐 己酰化 抗菌活性 

分 类 号：O636.1[理学—高分子化学]