EGF61A／G基因多态性与黑色素瘤易感性关系的Meta分析  

Correlation between EGF 61A/G polymorphism and melanoma susceptibility:A Meta analysis

作　　者：何大莉[1] 曾照芳[1] 

机构地区：[1]重庆医科大学检验医学院,临床检验诊断学教育部重点实验室,重庆市重点实验室,重庆400016

出　　处：《激光杂志》2013年第4期110-111,共2页Laser Journal

摘　　要：目的:评价EGF 61A/G基因多态性与黑色素瘤的相关性。方法:全面检索CNKI、CMCI、CBMDISC、VIP、EMBASE、PubMed、GoogleScholar、Web ofScience数据库,收集EGF 61A/G基因多态性与黑色素瘤相关性的文献。用Meta分析方法评价EGF 61A/G各基因型分布在黑色素瘤组与对照组中是否有差异。结果:共纳入6篇文献,共有黑色素瘤患者2175例,健康对照3952例。Meta分析未发现EGF 61A/G基因多态性与黑色素瘤具有相关性。结论:本研究未鉴定出EGF 61A/G基因多态性与黑色素瘤的相关性。Objective：To evaluate the correlation between epiderrnal growth factor（ EGF 61A/G） gene polymorhism anti melanoma susceptibility. Methcxts We searched CNKI,CMCI,CBMDISC, VIP , EMBASE, PubMed, Google Scholar, Web of Science database and collected all the publications about the correlation between FGF 61A/G polymoprphism and melanoma susceptibility, Meta analysis was performed for assessing the difference of EGF 61A/G genotype distribution hetween two groups （melanoma group anti control group）. Results A total of 6 studies involving 2175 melanoma palienls and 3952 healthy controls were included. The meta analysis showed that, there was no significant correlation between EGF 61A/G gene polymorphism and melanoma susceptibility. Conclusion This recta analysis didn＇t demonstrate the correlation between EGF 61A/G gene polymorphismand melanoma .susceptibility.

关 键 词：表皮生长因子 基因多态性 病例对照研究 黑色素瘤 恶性肿瘤 META分析 

分 类 号：TN248.1[电子电信—物理电子学]