支气管哮喘病因和发病机制的研究进展  

New progresses of causes and pathogenesis of bronchial asthma

作　　者：冯湘平[1] 赵辉[1] 陆强[1] 

机构地区：[1]天津市人民医院呼吸科,300121

出　　处：《国际呼吸杂志》2013年第15期1170-1173,共4页International Journal of Respiration

摘　　要：目前认为Th1／Th2型免疫应答失衡，是支气管哮喘（简称哮喘）发病的一个重要的免疫学机制。最近研究发现，哮喘的发病机制与许多因素有关。综述如下：吸烟是哮喘发病的危险因素之一。Th17及相关的细胞因子在哮喘中起着重要的作用。IL-33在哮喘的发病机制中起到重要的介导作用。MicroRNA的主要功能是在转录后水平调节相关基因表达，进而对机体生长、发育以及疾病发生过程调控。骨形成蛋白参与多种组织的纤维化进程，Gremlin是一种骨形成蛋白拮抗剂，探讨其在哮喘中的分布及作用，为哮喘发病机制的研究及治疗提供新的思路。脂肪细胞型脂肪酸结合蛋白在哮喘中发挥重要作用。The current study shows that the disorders of the Th1/Th2＇s immune function play an important role in the pathogenesis of bronchial asthma （asthma）. Recently, growing evidence demonstrates that the pathogenesis of asthma is related with many factors. Among them, cigarette smoking is a well-known risk factor for the onset of athma. Th17 ceils and its related cytokines play crucial roles in the development of asthma. Interleukin-33 plays a crucial role in the pathogenesis of asthma. MicroRNA play an important role in the regulation of genes expression post-transcriptionlly,and they also modulate growth of cells and development of organs. Bone morphogenetic proteins participate in the process of fibrosis in many tissues. Gremlin is an inhibitor of BMPs. It provide new thinking for the investigation of pathogenesis and treatment of asthma that summarize the expression and efffec of BMPs and gremlin in asthma. Adipocyte fatty acid binding protein may play an important role in asthma.

关 键 词：吸烟 TH17细胞 白介素33 MICRORNA 骨形成蛋白 脂肪细胞型脂肪酸结合蛋白 支气 管哮喘 

分 类 号：R562.25[医药卫生—呼吸系统]