498株念珠菌菌种分布及耐药性分析  

Strain distribution and antimicrobial resistance analysis of 498 candida strains

作　　者：李政[1] 高玲[1] 王玉春[1] 蒋冬香[1] 

机构地区：[1]桂林医学院附属医院检验科,广西桂林541001

出　　处：《华夏医学》2013年第4期666-669,共4页Acta Medicinae Sinica

基　　金：广西壮族自治区卫生厅计划课题资助(Z2010297)

摘　　要：目的:分析住院患者真菌感染的种类及其耐药特点,为使用抗真菌药物提供病原学依据。方法:对2010年3月至2012年3月临床送检标本检出的498株真菌进行培养鉴定和耐药性分析。结果:共检出498株念珠菌,其中白色念珠菌最多,为298株,占59.84%。其次,近平滑念珠菌91株,占18.27%。念珠菌来源以下呼吸道(63.86%)为主,其次为泌尿道(12.85%)、白带(8.84%)、血液(4.82%)和肠道(4.42%)等。念珠菌菌属对氟康唑、伊曲康唑的耐药率较高,分别为22.8%和56.8%,而两性霉素B、5-氟胞嘧啶的耐药率较低,分别为7.9%和7.3%。结论:白色念珠菌是真菌感染的主要病原菌,临床治疗念珠菌感染时应结合菌种鉴定及药敏试验结果合理选择抗真菌药物。Objective： To provide etiological basis for application of antifungal drugs by analyzing the types of fungal infection and drug resistance in hospitalized patients. Methods. From Mar. 2010 to Mar. 2012,a total of 498 cultured strains of fungi were tested for drug-resistance. Results：A total of 498 candida strains were detected, most of which were C. albicans,298 strains, accounting for 59.84 % next, C. parapsilosis, 91 strains, 18.27%. They were respectively isolated from lower respiratory tract （63.86%）, urinary tract （12.85%）, leucorrhea （8.84%）, blood （4.82%） and in-testine tract （4. 42%）. The resistant rates to fluconazole, 22. 8% and itraconazole, 56.8% were relatively higher than amphotericin B, 7.9 % and 5-fluorocytosine,7.3%. Conclusion：C. albicans is the main pathogen of fungal infection. Clinical antifungal therapy should be based on the results of strain identification and antifungal susceptibility testing.

关 键 词：念珠菌 耐药性 抗真菌药物 

分 类 号：R379.4[医药卫生—病原生物学]