白细胞介素1α对多形核白细胞功能的促进作用  

Prolongation of human polymorphonuclear leukocyte function by IL-1α

作　　者：石敏[1] 吴曙光[1] 

机构地区：[1]第一军医大学药物研究所,广州510515

出　　处：《中国药理学通报》2000年第5期513-515,共3页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金!(No 396 7842 );广东省自然科学基金!(No96 0 36 6 )资助

摘　　要：目的　白细胞介素 1α(IL 1α)是一种在炎症反应中起关键作用的细胞因子 ,能抑制多形核白细胞 (PMN)凋亡 ,这可能会增加由PMN介导的细胞毒作用。因此 ,本实验观察了IL 1α对PMN功能的影响。方法　测定了PMN的细胞功能实验 ,包括 :PMN粘附于玻璃表面的伸展实验、细胞极化〔卟啉醇肉豆蔻酸乙酸酯 (PMA)和酵母多糖刺激后PMN形状改变能力〕 ,细胞吞噬细菌能力和PMA刺激后PMN产生超氧阴离子的能力实验。结果IL 1α可促进PMN的功能。结论　IL 1α在延长PMN吞噬细菌能力的同时 ,也能增加超氧阴离子产生 ,可能是IL 1α通过PMN介导的组织损伤而导致器官衰竭的因素之一。AIM Interleukin 1α(IL-1α), which is a pivotal cytokine in inflammatory response, can inhibit human polymorphonuclear leukocyte (PMN) apoptosis,which can enhance PMN-mediated cytoxicity. Therefore we research the effect of IL-1α on the change of PMN functions was studied. METHODS Functional capacity of PMN was assessed by spreading, polarization (shape change), superoxide anion production and phagocytosis. RESULTS IL-1α can prolong PMN function by the inhibition of PMN apoptosis. CONCLUSION IL-1α inhibits PMN apoptosis, resulting in a larger population of surviving PMN with a greater capacity for phagocytosis and superoxide production. The later potentially facilitates PMN mediated tissue injury and may be one of mechanisms by which IL-1α contributes to organ dysfunction.

关 键 词：白细胞介素1Α 多形核白细胞功能 细胞伸展 

分 类 号：R392.12[医药卫生—免疫学] R329.24[医药卫生—基础医学]