TCDD对猕猴妊娠期及其妊娠结局的毒性影响  

The Effects of TCDD on Pregnant Cynomolgus Macaque (Macaca Fascicularis) and its Pregnancy Outcome

作　　者：郭玉梅[1] 王沭沂[1] 王心如[1] 

机构地区：[1]南京医科大学应用毒理学研究所,南京210029

出　　处：《中国公共卫生》2000年第11期1001-1002,共2页Chinese Journal of Public Health

摘　　要：在雌猴妊娠第 12天采用灌胃法一次性给予TCDD ,剂量为 1 0、2 0、4 0 μg/kg.bw ,每个剂量组 4个动物。对照组(7个动物 )给予相同体积的溶媒 (丙酮 -色拉油 )。结果发现母猴在染毒 10天后相继出现食欲下降、体重降低、脱毛、皮炎和贫血等中毒症状 ,染毒组 12只猴子有 10只在怀孕的第 2 2到 32天发生早期胚胎丢失。结果表明 ,低剂量TCDD可导致妊娠期猕猴出现中毒症状 ,并影响妊娠结局。Females macaques were administrated single doses of 1,2,4μg/kg TCDD(n=4 per dose group)on gestational day (GD)12.The controls(n=7)received the same dosing volume of acetone-coin oil.The results showed that poor appetite,weight loss,alopecia,dermatitis,anemia and other toxic reactions were recorded since rtrteatment day 10,and early fetal loss occurred between GD s 22 and 32 in 10 of the 12 animals treated,with TCDD.The results demonstrated that toxicity was induced by low level TCDD in pregnant macaques and pregnancy outcomes were affected too.

关 键 词：雌猕猴 TCDD 妊娠结局 毒性 四氯二苯二恶英 

分 类 号：R996[医药卫生—毒理学] R714.2[医药卫生—药学]