甲型H1N1流行性感冒病毒裂解疫苗的安全性监测  

Safety of Vaccine for A/H1N1 Influenza Split Virus

作　　者：李建坡[1] 李瑞芳[1] 李琦[2] 张连山[1] 张富斌[2] 尹增慧 

机构地区：[1]邯郸市疾病预防控制中心,河北邯郸056008 [2]河北省疾病预防控制中心 [3]武安市疾病预防控制中心

出　　处：《预防医学情报杂志》2013年第7期572-574,共3页Journal of Preventive Medicine Information

摘　　要：目的评价甲型H1N1流行性感冒裂解疫苗(甲流疫苗)的安全性。方法设立主动监测点,通过全国疑似预防接种异常反应(Adverse Events Following Immunization,AEFI)信息管理系统,收集邯郸市2009-10/2010-05接种甲流疫苗和主动监测点接种季节性流感疫苗后的AEFI个案信息,采用描述性方法对相关指标进行流行病学分析。结果邯郸市常规报告接种甲流疫苗717 288人,发生AEFI 105例,AEFI发生率14.64/10万,以一般反应为主,占88.57%,症状主要为38.5℃以下的低热,无严重不良反应和接种事故发生。主动监测点接种甲流疫苗1 993人,发生AEFI 15例,AEFI发生率752.63/10万,全部为一般反应,以发热为主。主动监测点接种季节性流感疫苗1 969人,发生AEFI 4例,AEFI发生率203.14/10万,全部为一般反应,均为发热。结论邯郸市监测点甲流疫苗接种后AEFI发生率高于季节性流感疫苗,反应类型以一般反应为主,且多为低热。甲流疫苗是安全的。Objective To evaluate the safety of vaccine for A/H1 N1 influenza split virus. Methods At surveil- lance spots, AEFI cases of A/H1N1 vaccine and seasonal influenza vaccine were collected through National Ad- verse Events Following Immunization （AEFI） Surveillance System. The data were analyzed with descriptive AEFI cases of influenza A/H1N1 vaccination was 14. 64/105, mainly general reactions with fever below 38.5 %. No serious adverse reactions and implementation of error ac- cidents occurred. The incidence of AEFI eases of influenza A/HI N1 vaccination was 752. 63/105, which were all general reactions and mostly fever. The incidence of AEFI cases of seasonal influenza vaccination was 203. 14/10 5, which were also all general reactions of fever. Conclusion The incidence of influenza A/H1N1 vaccination was higher than that of seasonal influenza vaccination, mild fever as the dominating reaction. Theinfluenza A/H1N1 vaccine was safe.

关 键 词：甲型H1N1流行性感冒但疫苗 预防接种 安全性 

分 类 号：R511.7[医药卫生—内科学]