甲状腺功能亢进症患者治疗前后骨密度与骨代谢生化指标变化的特点  

Analysis of the Changes of Bone Mineral Density and Bone Metabolic Biochemical Indexes before and after Treatment in Hyperthyroidism

作　　者：陈茹芬[1] 陈雪辉[1] 罗剑彬[1] 叶伟坚[1] 王梅珍[1] 黎秀娟[1] 

机构地区：[1]广东省惠州市中心人民医院核医学科,惠州516001

出　　处：《中国医药导刊》2013年第6期993-994,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:观察甲状腺功能亢进症(hyperthyroidism,甲亢)患者治疗前后骨密度与骨代谢生化指标变化的特点,以供临床参考。方法:以2011年6月～2012年6月我院收治的甲亢患者74例为研究对象,均给予口服甲巯咪唑、维生素D、乳酸钙、阿仑膦酸钠等药物治疗。连续用药1年,观察治疗前后Ca、P、ALP、UCa、UP等骨生化代谢指标的变化,并测定腰椎、股骨颈、大粗隆等部位BMD的差异。结果:与治疗前相比较,治疗后患者Ca、ALP、UCa明显下降,腰椎、股骨颈、大粗隆等部位BMD明显上升,有显著的统计学差异(P<0.05)。治疗前后P、UP比较,无统计学差异(P>0.05)。结论:在抗甲亢药物治疗基础上补充维生素D、钙剂和阿仑膦酸钠,可调节甲亢患者骨代谢,延缓骨质疏松进程,具有积极的临床意义。Objective：Observe the change of bone density and bone metabolic biochemical indexes before and after treatment in hyperthyroidism,for clinical reference.Methods：Choose 74 cases in Jan.to Dec.2010 in our hospital,give methimazole,vitamin D,calcium lactate,sodium alendronate.1 year later,observe changes of Ca,P,ALP,UCa,UP before and after treatment,and determinate BMD of lumbar spine,femoral neck,and trochanter.Results：Compared with before treatment,Ca,ALP,UCa decreased after treatment,BMD of lumbar spine,femoral neck,trochanter increased,has statistically significant difference（P〈0.05）.Comparison of P,UP before and after treatment,has no significant difference（P〈0.05）.Conclusion：On the basis of antithyroid drug therapy,vitamin D,calcium and sodium alendronate,can regulate bone metabolism of hyperthyroidism,delay the process of osteoporosis,has positive clinical significance.

关 键 词：甲亢 骨密度 骨代谢 

分 类 号：R581.1[医药卫生—内分泌]