改善胰岛素抵抗的单味中药成分和机制研究  

The Composition and Mechanism Research of Single Chinese Medical Herb Improving Insulin Resistance

作　　者：赵轩[1] 高彦彬[1] 

机构地区：[1]首都医科大学中医药学院,北京100069

出　　处：《世界中医药》2013年第7期840-843,共4页World Chinese Medicine

基　　金：北京市自然科学基金资助课题(编号:7122020)

摘　　要：参阅国内外相关文献33篇,概述了近年来单味中药及其提取物改善胰岛素抵抗的有效成分和作用机制研究,大量的临床试验和动物实验证明,许多单味中药及其提取物具有良好的改善胰岛素抵抗的作用,其有效成分主要有黄酮、生物碱、皂苷、多糖等;改善胰岛素抵抗的作用机制主要为刺激β细胞分泌胰岛素,增加胰岛素受体数目、增强胰岛素的敏感性,抑制胰岛素拮抗物质的分泌以及促进葡萄糖降解,最终达到改善IR的作用。Based on the related literature and articles home and abroad,we reviewed effective composite and mechanism of action of single Chinese medical herb and its extract that improves insulin resistance. A large number of clinical studies and animal experiments proved that many traditional Chinese medicines and its extract have good effect in improving insulin resistance. The effective ingredients are mainly flavonoids,alkaloids,saponins,polysaccharides,etc. ; the mechanism of action of insulin resistance include stimulating insulin by beta cells,increasing insulin receptor number and insulin sensitivity,inhibiting the secretion of insulin antagonistic material and promoting glucose degradation,thus ultimately improve the effect of IR.

关 键 词：单味中药 胰岛素抵抗 有效成分 作用机制 

分 类 号：R587.1[医药卫生—内分泌]