动脉硬化闭塞症中医证候与血清hsCRP、TNF-α表达的研究  

Study of Chinese Medical Syndromes and Serum Levels of hsCRP and TNF-α in Arteriosclerosis Obliterans

作　　者：李广平 李大勇[2] 

机构地区：[1]凤城市中医院外科,辽宁凤城118100 [2]辽宁中医药大学附属医院外科,辽宁沈阳110032

出　　处：《中华中医药学刊》2013年第8期1619-1620,共2页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(81173273);辽宁省自然科学基金资助项目(201202154);辽宁省高等学校优秀人才支持计划项目(LJQ2012083);沈阳市科学技术资助项目(F12-277-1-73)

摘　　要：目的:探讨血清hsCRP、TNF-α的表达水平与动脉硬化闭塞症中医证候的关系。方法:选取ASO寒湿证8例,血瘀证15例,热毒证12例,健康体检者10例为对照,检测血清hsCRP、TNF-α水平。结果:与对照组比较,ASO寒湿证组血清hsCRP、TNF-α水平轻度升高,ASO血瘀证组和热毒证组血清hsCRP、TNF-α水平明显升高(P<0.01)。结论:hsCRP、TNF-α参与了ASO的发生发展,血瘀证和热毒证ASO治疗过程中应重视炎性反应的控制。Objective：To study the relationship between serum levels of hsCRP, TNF -a and Chinese medical syn- dromes in arteriosclerosis obliterans （ASO）. Methodz ： All 35 cases with ASO were divided into cold type group, blood sta- sis group and heat toxin group, their serum levels of hsCRP and TNF - a were detected. Results ： Compared with the con- trol group, serum levels of hsCRP and TNF - oL increased slightly at cold type group, significantly increased at blood sta- sis group and heat toxin group （ P 〈 0. 01 ）. Conclusions ： The hsCRP and TNF - a participate in the occurrence and devel- opment of ASO, when treating ASO with blood stasis syndrome and heat toxin syndrome, it should pay attention to control inflammatory reaction.

关 键 词：动脉硬化闭塞症 高敏C反应蛋白 肿瘤坏死因子 

分 类 号：R543[医药卫生—心血管疾病]