养阴降糖片联合银杏叶片对早期2型糖尿病氧化应激与胰岛素抵抗的干预  

Clinical Effects of Yangyinjiangtang Tablets and Ginkgo Leaf Tablets Combination to the Oxidative Stress and Insulin-resistant in the Early Diabetes Type Ⅱ Patients

作　　者：王敬民 徐青 陈菊仙 杨伟 于占文 钟磊 

机构地区：[1]桐乡市中医院,浙江桐乡314500

出　　处：《中华中医药学刊》2013年第8期1677-1679,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：浙江省中医药科学研究基金资助项目(2011ZB149)

摘　　要：目的:观察养阴降糖片联合银杏叶片作为干预药物对早期2型糖尿病患者氧化应激及胰岛素抵抗方面的作用。方法:将139例早期2型糖尿病患者随机分为两组,实验组(基础治疗+养阴降糖片+银杏叶片)104例,对照组(基础治疗)35例,观察两组治疗前后血糖(FBG、PBG)、空腹胰岛素(FINS)、丙二醛(MDA)、超氧化物歧化酶(SOD)、谷胱甘肽(GSH)、胰岛素抵抗指数(HOMA-IR)变化的情况。结果:实验组MDA、GSH、SOD、FBG的变化均具有统计学意义(P﹤0.01),FINS、HOMA-IR变化无统计学意义(P﹥0.05);对照组MDA、FBG的变化具有统计学意义(P﹤0.01),GSH、SOD、FINS、HOMA-IR均无统计学意义(P﹥0.05)。结论:联合使用养阴降糖片和银杏叶片可降低早期2型糖尿病患者的氧化应激损伤,而对胰岛素抵抗无明显作用。Objectives ： To observe the clinical effects of Yangyinjiangtang tablets and Ginkgo leaf tablets to the oxida- tive stress and insulin -resistant in the patients who suffered from early diabetes type II. Methods ：139 early diabetes type II patients were divided into two groups randomly, 104 patients for group treatment who received basic treatment, Yangy- injiangtang tablets and Ginkgo leaf tablets ; other 35 patients for contrast treatment observation. Biochemical indices such as FBG, PBG, FINS, MDA, SOD, GSH and HOMA -IR weie detected before and after treatment in both two groups. Results：There is statistical significant difference of MDA, GSH, SOD and FBG in group experiment （P 〈 0. 01 ）, but thereis no statistical significance of FINS and HOMA- IR in this group（P 〉 O. 05 ）. In the contrast group, there is statistical significant difference of MDA and FBG （P 〈0.01 ）, but there is no statistical significance of GSH, SOD, FINS and HO- MA - IR in this group （P 〉 0.05 ）. Conclusion： Combined use of Yangyinjiangtang tablets and Ginkgo leaf tablets could re- duce oxidative stress effect, but there is no clinical efficacy of treating insulin - resistant.

关 键 词：早期2型糖尿病 养阴降糖片 银杏叶片 氧化应激 

分 类 号：R587.1[医药卫生—内分泌]