补气化瘀通络方治疗干燥综合征临床疗效及对免疫球蛋白的影响  

Clinical Efficacy of Buqi Huaxue Tongluo Formula in Treatment of Sjogren's Syndrome and Its Influence on Immunoglobulin

作　　者：孙剑虹[1] 徐串联[1] 严宇仙[1] 

机构地区：[1]常山县人民医院,浙江常山324200

出　　处：《中华中医药学刊》2013年第8期1770-1772,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：常山县科技立项课题资助项目(2012077)

摘　　要：目的:研究补气化瘀通络方治疗干燥综合征(Sjogren's syndrome,SS)临床疗效及作用机理。方法:将60例SS患者随机分为两组,对照组30例用西药常规治疗,治疗组30例用补气化瘀通络方治疗,另选30名健康者作为健康组。治疗前后分别测定健康组和两组SS患者免疫球蛋白含量;并观察治疗组和对照组的症状积分、临床疗效、免疫球蛋白等的变化情况。结果:治疗组相对于对照组病情稳定时间短,治疗的副作用小,复发率低,各项指标均优于对照组(P<0.05)。SS患者免疫球蛋白含量较健康组显著增高(P<0.01),治疗组能显著降低免疫球蛋白含量(P<0.01)。结论:补气化瘀通络方治疗SS安全有效,可以减轻病症,降低免疫球蛋白含量,且有一定的免疫调节作用。Objective： To study the clinical efficacy and mechanism of Buqi Huaxue Tongluo Formula in treatment of Sjogren syndrome （SS）. Methods： 60 cases of SS patients were randomly divided into two groups, control group, in which 30 cases were given conventional Western medicine, and the treatment group,in which 30 cases were given Buqi Huaxue Tongluo Formula. Another 30 healthy subjects were as health group. The immune globulin contents in healthy group and two groups of SS patients were measured before and after treatment; and the changes of symptom scores, clini- cal efficacy, immune globulin in treatment group and control group were observed. Results： Compared to the control group, the treatment group was in a stable condition with shorter time, the side effects were fewer and the recurrence rate was low, indicators were better than those in the control group （P 〈 0. 05 ）. Compared with the healthy, the immune glob- ulin content of SS patients was significantly higher （P 〈 0. 01 ） , treatment group could significantly lower immunoglobulin content （P 〈 0. 01 ）. Conclusion ： Buqi Hnayu Tongluo Formula in treatment of SS is safe and can alleviate symptoms and reduce the immunoglobulin content, and regulate immune fuctions.

关 键 词：干燥综合征 免疫球蛋白 补气化瘀通络方 

分 类 号：R593[医药卫生—内科学]