臭氧联合阿德福韦脂胶囊治疗乙型肝炎的安全性评估  

Safety Assessment of Ozone Adefovir Fat Capsules in the Treatment of Hepatitis B

作　　者：朱文平[1] 安良敏 李连娣[1] 

机构地区：[1]广东省英德市人民医院药学部,广东英德513000

出　　处：《中国医药指南》2013年第20期23-24,共2页Guide of China Medicine

摘　　要：目的探讨臭氧联合阿德福韦酯胶囊治疗乙型肝炎的效果,并进行安全性评估。方法选择我院80例乙型肝炎患者随机分为对照组和观察组,每组40例,对照组患者采用阿德福韦酯胶囊治疗,观察组患者采用臭氧联合阿德福韦酯胶囊治疗,疗程结束后,观察两组患者治疗后3、6、12、18个月HBV-DNA、HbeAg转阴率、病毒应答及不良反应。结果观察组在治疗后12、18个月血清HBV-DNA、HbeAg转阴率均高于对照组,完全应答与持续应答率明显高于对照组,无应答率低于对照组,两组间比较差异具有显著性(P<0.05)。观察组在臭氧治疗过程中出现1例不良反应,发生率为2.5%;对照组无明显不良反应病例。结论臭氧联合阿德福韦酯胶囊治疗乙型肝炎具有治疗效果好、见效快的优点,且无明显的不良反应,安全性较高。Objective To study the effect of ozone combined with adefovir dipivoxil capsules for the treatment of hepatitis B, and safety assessment. Method Select our hospital 80 cases of hepatitis B were randomLy divided into control group and observation group, 40 cases in each group, the control group were treated with adefovir dipivoxil capsules treatment, the observation group were treated with ozone combined with adefovir dipivoxil capsules treatment the end of treatment was observed after 3, 6, 12, 18 months after the treatment of the two groups of patients with HBV-DNA, HBeAg-negative rate of virologic response and adverse reactions. Results The 12 and 18 months of serum HBV-DNA, HBeAg-negative rate was higher complete response and sustained response rate after treatment was significantly higher response rate than the control group, two groupsThe difference being significant （P〈0.05）. Observation group in the process of ozone therapy in cases of adverse reactions, the rate was 2.5%; no significant adverse reactions occurred in the control group. Conclusion Ozone combined with adefovir dipivoxil capsules treatment of hepatitis B with a good therapeutic effect, the advantages of quick, and no significant adverse reactions, high security.

关 键 词：臭氧 阿德福韦酯胶囊 乙型肝炎 效果 安全性 

分 类 号：R512.62[医药卫生—内科学]