PGC-1基因Gly482Ser多态与心肌梗死的相关研究  

Association of Gly482Ser Polymorphism in PGC-1 Gene with Myocardial Infarction

作　　者：赵丽荣 王立平[2] 

机构地区：[1]内蒙古自治区人民医院,内蒙古呼和浩特010017 [2]内蒙古医科大学附属医院心内科,内蒙古呼和浩特010050

出　　处：《内蒙古医学杂志》2013年第5期520-523,共4页Inner Mongolia Medical Journal

摘　　要：目的:旨在探讨过氧化物酶增殖物激活受体-γ共激活蛋白-1(peroxisome proliferator-activated receptor-γcoactivator-1,PGC-1)基因Gly482Ser多态与心肌梗死发生的相关性。方法:随机选取内蒙古地区汉族人255例,其中对照组134例,心肌梗死组121例。采用聚合酶链反应-限制性片段长度多态性技术(PCR-RFLP)进行基因型检测,并用直接测序法加以证实。结果:PGC-1基因Gly482Ser多态GG、GA、AA基因型频率在对照组分别为0.455、0.388、0.157,在病例组分别为0.099、0.843、0.058(P<0.01),GG vs.GA+AA,P<0.01),等位基因频率分布有明显差异(P=0.003);GA/AA基因型的心梗患者,其血清总胆固醇(TC)水平较GG基因型者明显升高(P<0.05)。结论:PGC-1基因Gly482Ser变异与心梗的发病危险显著相关。Objective：To explore the relationship between peroxisome prolife rator-activated receptor-γcoactivator-1（PGC-1） gene polymorphism and myocardial infarction（MI）.Methods：255 subjects of Inner Mongolia area were enrolled randomly including 134 subjects of control group（CG） and 121 subjects of MI.PCR-RFLP was adopted to detect genotype and was conformed by PCR sequencing.Results：The frequencies of GG、GAandAA in CG were 0.455、0.388 and 0.157 respectively and 0.099、0.843、0.058 in MI（P0.01）,（GG vs.GA＋AA,P0.01）.The distribution of allele frequencies was significantly different（P=0.003）;The total cholesterol（TC）level of GA/AA genotype subjects was higher than GG genotype subjects（P0.05）in MI.Conclusion：PGC-1 gene Gly482Ser polymorphism was associated with an increased risk of MI.

关 键 词：PGC-1基因多态 Gly482Ser变异 心肌梗死 

分 类 号：R542.22[医药卫生—心血管疾病]