中药寒热药性与线粒体能量代谢关系研究  

Advances in Researches on Relations between Cold and Hot Properties of TCM and Mitochondrial Energy Metabolism

作　　者：王艳艳[1] 孙雪[1] 裴晓蕾[1] 王秋红[1] 杨炳友[1] 匡海学[1] 

机构地区：[1]黑龙江中医药大学北药基础与应用研究省部共建教育部重点实验室黑龙江省中药及天然药物药效物质基础研究重点实验室,黑龙江哈尔滨150040

出　　处：《中医药信息》2013年第4期48-50,共3页Information on Traditional Chinese Medicine

基　　金：国家重点基础研究发展计划973计划课题(2013CB531800)

摘　　要：中药具有寒,热之性,寒热药性是从药物的作用性质上对药物多种医疗作用的高度概括,是中药药性理论的核心内容。总结和反思寒热药性研究的前期成果发现,中医的寒证、热证与机体能量代谢的关系密切,寒热中药可能通过影响能量代谢的某些环节,实现对寒热证的调节。线粒体是细胞氧化供能的重要部位,线粒体中的关键酶、解偶联蛋白以及三羧酸循环节点代谢产物等在调控能量代谢方面发挥重要作用。基于线粒体能量代谢的中药寒热药性研究为揭示药性的本质研究提供了一个新的思路。Traditional Chinese medicine （TCM） has the nature of cold and hot. Cold and hot properties are highly summarized that are from the nature of drug on a wide range of medical role, which is the core content of the theory of Chinese medicine properties. Summary and reflection of cold and hot properties that are from pre- liminary results show that it is closely related to the body＇s energy metabolism. Chills and fever Chinese medi- cine may affect some links of energy metabolism, achieve the regulation of symptoms caused by cold and hot factors. Mitochondria is the essential part of cellular oxidative and energy supply, key enzyme, uncoupling pro- rein, and citric acid cycle node metabolites in mitochondria play an important role in the regula metabolism. Study of cold and hot properties based on mitochondrial energy metabolism provides thinking for revealing the herbal essence. tion of energy a new way of

关 键 词：中药 寒热药性 线粒体 能量代谢 

分 类 号：R285.1[医药卫生—中药学]