健脾补肾活血法联合小剂量雄激素治疗慢性再生障碍性贫血的临床观察  

Treatment for Chronic Aplastic Anemia by Strengthening the Spleen,Invigorating the Kidney and Activating Blood Circulation Combined with Small Dose of Androgen

作　　者：陈海琳[1] 孙伟玲[1] 周永明[1] 杜美莲[1] 胡明辉[1] 朱文伟[1] 鲍计章[1] 胡令彦[1] 王婕[1] 陆皓[1] 

机构地区：[1]上海中医药大学附属岳阳中西医结合医院,上海200437

出　　处：《中医药信息》2013年第4期113-117,共5页Information on Traditional Chinese Medicine

基　　金：上海市卫生局中医药科研基金项目(2010QL019A);上海中医药大学附属岳阳中西医结合医院周永明工作室(sy200902)

摘　　要：目的:观察以健脾补肾活血法为主联合小剂量雄性激素等组成的综合方案治疗慢性再生障碍性贫血的临床疗效。方法:将符合纳入标准的91例慢性再障患者随机分为治疗组61例和对照组30例,治疗组又分为脾肾阳虚型组(31例)服用生血Ⅰ号合剂,脾肾阴虚型组(30例)服用生血Ⅱ号合剂;对照组服用复方皂矾丸,所有患者均联合服用小剂量雄性激素。两组均施以对症及支持治疗,治疗3个月为1个疗程,连用2个疗程以上进行临床证候疗效评估较。结果:对中医临床证候改善,治疗组中医证候好转明显优于对照组(P<0.05)。治疗组和对照组依赖红细胞悬液患者月均输注量均较治疗前减少,两者无显著差异(P<0.01),但治疗组依赖红细胞悬液患者比率减少较对照组明显(P<0.05)。依赖血小板悬液输注患者,治疗组减少率大于对照组(P<0.05)。治疗组感染发生率较对照组下降(P<0.05)。结论:健脾补肾活血法为主联合小剂量雄性激素等组成的综合方案治疗慢性再生障碍性贫血的临床疗效良好。Objective： To investigate the remedy with strengthening the spleen, tonifying the kidney and activa- ting blood circulation combined with small dose of male hormone in the treatment of chronic aplastic anemia. Methods： 91 patients of chronic aplastic anemia （CAA） were divided into treatment group with 61 cases and control group with 30 cases. According to the syndrome differentiation, the patients in the treatment group were subdivided into Yang deficiency of spleen and kidney （31 cases） and yin deficiency of the spleen and kidney （30 cases）. Patients with Yang deficiency took Shengxue mixture No. 1; Patients with Yin deficiency took Shengxue mixture No. 2. The control group was treated with compound Zaofan Pill. All patients were treated additionally with small dose of androgen. The patients were received more than two courses of treat- ment, each for three months, in the mean time, symptomatic and supportive treatment was given if necessary. The efficacy of the remedy was evaluated. Results： The curative effect on TCM syndrome was better in the treatment group than that in the control group （P 〈 0.05 ）. Both in the treatment group and control group, CAA patients depending on red cell suspension infusion reduced the volume of red cell suspension infusion per month after treatment. However, the rate of CAA patients depending on red cell suspension infusion was re- duced more in the treatment group than that in the control group. CAA patients depending on platelet suspen- sion infusion reduced more volume of platelet suspension infusion in the treatment than that that in the control group （ P 〈 0.05 ）. The rate of complication with infection was lower in the treatment group than in the control group （ P 〈 0.05 ）. Conclusion ： The remedy with strengthening the spleen, tonifying the kidney and activating blood circulation combined with small dose of male hormone has a beneficial efficacy on the treatment of chronic aplastic anemia.

关 键 词：慢性再生障碍性贫血 健脾补肾活血法 生血合剂 中医药治疗 

分 类 号：R556.5[医药卫生—血液循环系统疾病]