结节性甲状腺肿术后促甲状腺激素抑制治疗效果的探讨  

The therapeutical effect of suppressive therapy after thyroidectomy in multinodular goiter patients

作　　者：孟繁杰[1] 李燕书[1] 马顺茂[1] 王海刚[1] 张立献[1] 曹斌[1] 

机构地区：[1]河北医科大学附属华北石油管理局总医院普外二科,河北任丘062552

出　　处：《中日友好医院学报》2013年第4期216-218,共3页Journal of China-Japan Friendship Hospital

基　　金：中国石油华北油田科技信息处基金2012-HB-G09-2

摘　　要：目的:观察结节性甲状腺肿患者手术后在不同时间给予抑制治疗后促甲状腺激素(TSH)水平的变化和2年后的复发率,探讨给予TSH抑制治疗的最佳时机。方法:将120例结节性甲状腺肿术后患者分为对照组(n=60)和实验组(n=60),对照组术后3周开始给药,实验组在术后第1d开始给药,药物为左甲状腺素,剂量均为100μg/d,每天早晨空腹顿服。于术后第3d、第5d、第9d、第14d及每个月检测血清促甲状腺激素(血清s-TSH)水平,比较2组TSH值的变化及其复发率。结果:与对照组相比,实验组术后s-TSH水平较早达到平稳(P<0.05),且其术后2年的复发率显著低于对照组(P<0.05)。结论:结节性甲状腺肿患者术后早期给予TSH抑制治疗能明显缩短其达到TSH平稳的时间,并且降低术后的复发率。Objective：To study alterations of the serum TSH level and the 2 year recurrence rate after thyroidectomy in patients with multinodular goiter accepted suppressive therapy in different time after the operation.Methods：Sixty female patients with multinodular goiter were divided into control group（n=60）and experimental group（n=60）.The serum TSH test were done at day 3,day 5,day 9,day 14 and every month after thyroidectomy.Results：Compared with control group,the serum TSH levels in experimental group achieved expected value quickly and smoothly and had a lower relapse rate in two years.Conclusion：If patients with multinodular goiter after thyroidectomy start the suppressive therapy early,they would achieve an expected TSH value quickly and smoothly,and have a lower postoperative recurrence rate.

关 键 词：甲状腺激素 结节性甲状腺肿 甲状腺切除术 抑制 

分 类 号：R581.3[医药卫生—内分泌]