肺心病患者急性加重期血清一氧化氮、内皮素及心钠素含量变化的意义  

Significance of the changes of serum nitric oxide ,endothelin 1 and atrial natriuretic peptides in chronic cor pulmonale with acute exacerbation

作　　者：颜浩[1] 周黎强[1] 黎怀碧[1] 张蕾[1] 

机构地区：[1]成都市第二人民医院,610017

出　　处：《四川医学》2000年第6期477-478,共2页Sichuan Medical Journal

摘　　要：目的　探讨慢性肺心病急性加重期血清一氧化氮 (NO)、内皮素 (ET- 1)及心钠素 (ANP)含量变化的意义。方法　收集慢性肺心病急性加重期患者 45例 (肺心病组 )及健康者 35例 (正常对照组 )。分别检测血清 NO、ET- 1及ANP含量 ;肺心病组其中 2 8例同时检测动脉血氧分压 (Pa O2 ) ,观察血清 NO、ET- 1及 ANP含量和 Pa O2 的相关性。结果　肺心病组血清 NO、ET- 1及 ANP含量分别为 5 2± 2 7.6 umol/ L ,6 7± 2 7.4ng/ L ,2 72± 94ng/ ml,明显高于正常对照组 ,P<0 .0 1;肺心病组 ET- 1及 ANP含量和 Pa O2 呈负相关 ,NO含量和 Pa O2 无相关性。结论　 NO、ET- 1及 ANP参与了慢性肺心病的形成 ,而血清 ET- 1及 ANP含量检测有助于评估慢性肺心病急性加重期低氧程度 ,血清Objective To evaluate the significance of the changes of serum nitric oxide(NO),endothe lin 1(ET 1),atrial natriuretic peptides(ANP) in chronic cor pulmonale with acute exacerbation.[WT5”HZ]Methods [WT5”BZ]The levels of serum NO,ET 1 and ANP were determined in 45 cases of chronic cor pulmonale with acute exacerbation and 35 normal controls respectively.PaO 2 was tested in 28 cases of chronic cor pulmonale with acute exacerbation.Results The levels of serum NO,ET 1 and ANP in chronic cor pulmonale with acute exacerbation were significantly higher than those of control group.The levels of serum ET 1 and ANP had significantly negative correlation with PaO 2,but there was no correlation between the levels of serum NO and PaO 2.[WT5”HZ]Conclusion [WT5”BZ]The increase of serum ET 1 and ANP are closely associated with the severity of anoxia in chronic cor pumonale with acute exacerbation;the increase of NO in serum is correlated with airway inflammation.

关 键 词：肺心病 一氧化氮 内皮素 心钠素 急性加重期 

分 类 号：R541.5[医药卫生—心血管疾病]