大规模接种前抗体水平对甲型H1N1流行性感冒疫苗免疫原性和免疫持久性的影响  

Influence of Pre-vaccination Antibody Titer on Immunogenicity and Immune Persistence of Influenza A(H1N1) Vaccine

作　　者：李瑞芳[1] 李建坡[1] 马玉忠[1] 王峻巍[1] 张振国[2] 张连山[1] 李琦[2] 

机构地区：[1]河北省邯郸市疾病预防控制中心,河北邯郸056008 [2]河北省疾病预防控制中心

出　　处：《实用预防医学》2013年第8期944-946,共3页Practical Preventive Medicine

摘　　要：目的探讨大规模接种前抗体水平对甲型H1N1流行性感冒裂解疫苗（简称甲流疫苗）免疫原性和免疫持久性的影响。方法采用多阶段随机抽样方法，抽取3--5岁、6～10岁、11～15岁、16～20岁、21～40岁、41～60岁和60岁以上7个年龄组计350人作为监测对象。使用微量血凝抑制（HI）实验测定监测对象接种甲流疫苗前、接种后28d和6个月甲流抗体水平。计算抗体平均滴度、抗体阳转率和抗体保护率，分析接种前抗体水平与抗体阳性率、抗体保护率的关系。结果接种前HI抗体平均滴度1：6．65，抗体保护率17．1％，接种后28d和6个月甲流HI抗体平均滴度、阳转率和保护率均超过了欧盟药品评价局（EMEA）和美国FDA的标准。接种前抗体水平与免疫后28d和6个月抗体阳转率均呈负相关，与抗体保护率均无相关性。结论甲流流行期间，为了提高保护率，保护易感人群，可以不考虑接种前抗体水平，并可取得较好的免疫原性和免疫持久性。Objective To explore the impact of pre - vaccination antibody titer on immunogenicity and immune persis- tence of influenza A （H1N1） vaccine. Methods Multi - stage random sampling method was adopted to select 350 monitoring objects from people aged 3 - 5 years, 6 - 10 years, 11 - 15 years, 16 - 20 years, 21 - 40 years, 41 - 60 years and over 60 years. The micro- bemagglutination inhibition （HI） experiment was used to determine their antibody levels before the vaccine inocula- tion, 28 days and 6 months after the vaccination. The mean titer of antibody, seroconversion rate and seroprotection rate were calculated. The relationships between the pre-vaccination antibody titer and seroconversion rate, seroprotecrion rate were ana- lyzed. Results Before the vaccination, the mean titer of HI antibody in the monitoring crowd was 1 ： 6.65 and the seropro- tection rate was 17.1%. 28 days and 6 months after the vaccination, the mean titer of HI antibody, seroconversion rate and se- roprotection rate exceeded the standards of the EMEA and the U.S. FDA. The pre - vaccination antibody titer was negatively correlated with the seroconversion rates of 28 days and 6 months after the vaccination, but had no correlation with the seroprotec- tion rate. Conclusions In order to improve the seroprotection rate and protect the susceptible population during the influenza A （H1N1） pandemic, pre-vaccination antibody titer can be ignored when influenza A （H1N1） vaccine uses in the susceptible; meanwhile, good immunogenicity and immune persistence can be obtained.

关 键 词：甲型H1N1流行性感冒疫苗 抗体 免疫原性 免疫持久性 

分 类 号：R186[医药卫生—流行病学]