替硝唑防治女性生殖道厌氧菌感染的作用评价  

Evaluation of Tinidazole Injection in the Prevention and Treatment of Anaerobe Infections in Female Genital Tract

作　　者：黄庆华[1] 龚婷 张玉兰 马庭元 吴熙瑞 吴珊 

机构地区：[1]同济医科大学微生物教研室,430030 [2]同济医院妇产科,430030

出　　处：《医药导报》2000年第3期207-208,共2页Herald of Medicine

摘　　要：探讨替硝唑 (TNZ)注射液防治妇产科疾患及手术患者厌氧菌感染的作用 ,并与甲硝唑 (MNZ)注射液进行比较。方法 :静脉滴注每 2 0 0ml含TNZ 80 0mg或每 2 0 0ml含MNZ 10 0 0mg ,疗程妇科 5d ,产科 3d。用药前后分别做厌氧菌分离培养 ,并比较两种注射液对 3株标准株和 10 7株临床分离厌氧菌的抗菌活性。结果 :TNZ组和MNZ组厌氧菌转阴或明显减少者分别为 91.0 %和 44.0 % ,有效率 94.0 %和 82 .0 %。提示TNZ对厌氧菌的抑制程度和疗效均明显优于MNZ(P <0 .0 1)。体外药敏试验结果亦证实 ,TNZ的药物敏感率 >MNZ ,前者的MIC和MBC为 0 .39～ 5 0 .0 0mg L ,后者为0 .78～ 10 0 .0 0mg L。结论 :TNZ防治女性生殖道厌氧菌感染明显优于MNZ。Objective:To evaluate the value of tinidazole (TNZ) injection in the prevention and treatment of obstetrical and gynecological patients with anaerobic infecitons in comparison with metronidazole (MNZ) injection. Method:A dose of 800 mg/200 ml TNZ or 1 000 mg/200 ml MNZ were intravenously infused daily. The gynecological patients received the treatment for 5 days, and the obstetric patients for 3 days. The isolation and culture for anaerobes were performed before and after treatment. At the same time, antibacterial activity in vitro of TNZ against 3 reference strains and 107 anaerobes isolated from patients was examined and compared with the activity of MNZ. Results:The eradication rate or obvious reduction rate of anaerobic bacteria in TNZ group and MNZ group were 91.0% and 44.0%, respectively. The total clinical effective rate of both injections were 94.0% and 82.0%, respectively. The results showed that the clinical efficacy of TNZ against anaerobes was higher than that of MNZ (P<0.01). The both activities in vitro were confirmed also that TNZ was better than MNZ, MICs and MBCs were 0.39-50.00 mg/L and 0.78-100.00 mg/L, respectively. Conclusion:TNZ is more effective than MNZ in the prevention and treatment of anaerobic bacterial infection in female genital tract.

关 键 词：替硝唑注射液 女性 生殖道 厌氧菌感染 

分 类 号：R984[医药卫生—药品] R711.305[医药卫生—药学]