普罗布考、阿托伐他汀对老年高血压病颈动脉粥样硬化的影响  

Effect of Probucol Combined with Atorvastatin on Elderly Patients with Carotid Atherosclerosis

作　　者：蒋美媛[1] 庞明[1] 陈敏[1] 严红[1] 余艳[1] 黎华[1] 

机构地区：[1]广西壮族自治区江滨医院,南宁市530021

出　　处：《广西医学》2013年第8期980-983,共4页Guangxi Medical Journal

基　　金：广西自然科学基金(0991195)

摘　　要：目的观察普罗布考联合阿托伐他汀对老年高血压病合并颈动脉粥样硬化的影响。方法将60例高血压病合并颈动脉内膜中层厚度(IMT)增厚和(或)颈动脉粥样硬化斑块患者,按入院就诊单双号分成普罗布考治疗组、普罗布考联合阿托伐他汀治疗组(联合组)各30例,疗程6个月。观察两组治疗前后颈动脉IMT厚度及颈动脉粥样硬化斑块面积变化及血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、氧化型低密度脂蛋白(ox-LDL)和高敏C反应蛋白(hs-CRP)水平的变化。结果治疗后两组颈动脉IMT、颈动脉内膜斑块面积均减小(P<0.05),而且联合组颈动脉IMT、颈动脉内膜斑块面积减少更为显著(P<0.01)。两组治疗后TC、TG、LDL-C、ox-LDL、hs-CRP比治疗前均明显下降,并且联合组上述指标明显低于普罗布考组(P均<0.01)。结论普罗布考联合阿托伐他汀治疗老年高血压病合并颈动脉IMT增厚及粥样硬化斑块有显著疗效,无明显不良反应。Objective To observe the effect of probucol combined with atorvastatin on elderly hypertension patients with carotid atherosclerosis. Methods Sixty hypertension patients with thicken carotid intima-media thick- ness（IMT） and/or carotid atherosclerosis plaque were randomly divided into probucol group and probucol plus atorv- astatin group（ combination group） according to their admission numbers ,30 cases in each group. The treatment lasted for six months. The changes of carotid IMT and carotid atheiosclerosis plaque area, and levels of serum total cholester- ol （ TC ）, triglyceride （TG）, low-density lipoprotein cholesterol （ LDL-C ）, oxidized low density lipoprotein （ox-LDL） and high-sensitivity C-reactive protein（hs-CRP） were detected in both groups before and after treatment. Results Carot- id IMT and plaque areas decreased significantly in both group after treatment （P 〈 0.05 ）, the decrease in the combina- tion group was more significant（P 〈 0.01 ）. TC, TG, LDL-C, ox-LDL and hs-CRP decreased significantly after treat- ment in both groups compared with those before treatment, and the indices above in the combination group were signifi- cantly lower than those in the probucol group （ all P 〈 0.01 ）. Conclusion The therapy of probucol plus atorvastatin for the treatment of elderly hypertension patients with thicken carotid IMT and atherosclerosis plaque has significant effect without significant adverse reactions.

关 键 词：高血压 动脉粥样硬化 普罗布考 阿托伐他汀 

分 类 号：R543.4[医药卫生—心血管疾病]