无溶剂NH_2SO_3H催化下微波促进四氢吡喃-4-酮与芳香醛的Aldol缩合反应  

Aldol Condensation of Tetrahydro-4H-pyran-4-one and Aromatic Aldehydes Catalyzed by NH_2SO_3H Under Solvent-Free Conditions and Microwave Irradiation

作　　者：薛蒙伟[1] 张敦林[1] 刘光祥[1] 李健[1] 

机构地区：[1]南京晓庄学院生物化工与环境工程学院,江苏南京211171

出　　处：《合成化学》2013年第4期485-487,共3页Chinese Journal of Synthetic Chemistry

基　　金：国家自然科学基金资助项目(21271106)

摘　　要：以四氢吡喃-4-酮与芳香醛(1)为原料,NH2SO3H为催化剂,在无溶剂条件下,微波促进Aldol缩合反应合成了一系列3,5-二亚苄基四氢吡喃-4-酮衍生物(收率72%～92%),其结构经1H NMR,IR,MS和元素分析确证。最佳反应条件为:1 12 mmol,NH2SO3H用量40 mol%,于300 W微波辐射2 min～3 min。A series of 3,5-dibenzylidene-tetrahydropyran-4-one derivatives with yield of 72%～92% were synthesized by Aldol condensation of tetrahydro-4H-pyran-4-one with aromatic aldehydes（1） using NH2SO3H as the catalyst under solvent-free condition and microwave irradiation.The structures were confirmed by 1H NMR,IR,MS and elemental analysis.The optimum reaction conditions were as follows： 1 was 12 mmol,NH2SO3H amount was 40 mol%,microwave irradiation at 300 W for 2 min～3 min.

关 键 词：3 5-二亚苄基四氢吡喃-4-酮 微波 Aldol缩合 合成 

分 类 号：O626.3[理学—有机化学] O625.1[理学—化学]