急性冠状动脉综合征合并轻中度肾功能不全患者GRACE评分冠状动脉病变及6个月内预后研究  

GRACE scores,coronary artery stenosis and 6-months prognosis in patients with acute coronary syndrome complicated by mild to moderate renal insufficiency

作　　者：王亚蓉[1] 李彪[1] 陈耀贵[1] 

机构地区：[1]广州市红十字会医院,510220

出　　处：《山西医药杂志（上半月）》2013年第8期851-854,共4页Shanxi Medical Journal

基　　金：广东省科技计划项目(2009B060700017);广州市卫生科技项目(2008-YB-039)

摘　　要：目的研究急性冠状动脉综合征(ACS)合并轻中度肾功能不全患者全球急性冠状动脉综合征注册(GRACE)危险评分、冠状动脉病变及6个月心血管事件。方法研究入选我院心内科ACS患者263例,其中合并轻中度肾功能不全者128例,肾功能正常者135例。入选患者进行GRACE危险评分,并进行冠状动脉造影,并计算冠状动脉Gensini积分,所有患者随访观察6个月;比较2组GRACE评分、冠状动脉病变范围、冠状动脉Gensini积分、院内及6个月心血管事件发生率。结果肾功能不全组较对照组相比,GRACE评分分值增高(P<0.05),冠状动脉病变范围及病变程度更严重(P<0.05),6个月随访心血管事件发生率增高(P<0.05)。结论 ACS合并轻中度肾功能不全患者GRACE危险评分分值增加,冠状动脉病变的支数及狭窄的程度更严重,心血管事件发生率高,预后差。Objective To study the Global Registry of Acute Coronary Events （GRACE）scores, coronary artery stenosis and 6-months prognosis in patients with ACS complicated by mild to moderate renal insufficiency. Methods Two hundred and sixty-three patients with ACS were divided into two groups： complicated by mild to moderate renal insufficiency group （n= 128） and normal renal function group （n= 135）. GRACE scores were gra- ded and coronary artery angiography was performed in all patients. GRACE scores and coronary artery stenosis was compared between two groups. The incidence rate of 6-month end event in two groups was analyzed. Results Present study shows that GRACE scores increased （P〈0. 05）, the severity and number of pathological arteries increased （P〈0. 05）, and incidence rate of 6-month end event increased （P〈0.05） in patients with ACS compli-cated by mild to moderate renal insufficiency compared with normal renal function. Conclusion GRACE scores, coronary lesions and incidence rate of 6-month end event increased in patients with ACS complicated by mild to moderate renal insufficiency compared with normal renal function.

关 键 词：冠状动脉疾病 GRACE评分 冠状动脉病变 心血管事件 

分 类 号：R541.4[医药卫生—心血管疾病]