高压氧影响游离植骨种植体骨整合的组织学研究  

Histologic study of the effects of hyperbaric oxygen therapy on implant osseointegration in autogenous free bone grafts

作　　者：蒋立坚[1] 陈光晔[2] 陈伟良[2] 陈小华 

机构地区：[1]中山医科大学附属第三医院口腔科,510630 [2]孙逸仙纪念医院口腔科 [3]光华口腔医院病理科

出　　处：《实用口腔医学杂志》2000年第4期285-287,共3页Journal of Practical Stomatology

摘　　要：目的：探讨高压氧能否促进种植体在非血管化新鲜自体游离移植骨上形成骨整合。方法：选用４只杂种成年狗，随机分成２组，每组２只，在狗下颌骨下缘各截取４ｃｍ×１．５ｃｍ大小的方形骨块，完全游离后原位植入，在植骨块上种入２个ＨＡ种植体。实验组动物在术后第 ３天开始进行高压氧（ＨＢＯ）治疗（２４．２ ｋＰａ、１．５ｈ／ｄ、５ｄ／周，共 ４周），术后１０周处死 ４只动物，取含种植体的骨块，脱钙后腊包埋、切片、ＨＥ染色、组织学观察。结果：ＨＢＯ组种植体在移植骨上形成骨整合，种植体周围的新骨呈连续的骨界面。非ＨＢＯ组种植体界面呈不连续的新骨界面。结论：羟基磷灰石涂层种植体可在非血管化自体游离移植骨上形成骨整合，ＨＢＯ可以促进骨结合的形成。To clarify the effects of hyperbaric oxygen (HBO) on osseointegrated implants in non-vascularized bone graft (NVBG). Methods: Four adult dogs were used in the study. A 4. 0 cm × 1. 5 cm bone block was resected from the body of the mandible and replaced to their original place bilaterally in each dog, 2 hydroxylapatite-coated implants were placed in each bone graft. The animals were randomly divided into HBO treated and non-HBO groups. The dogs were sacrificed 10 weeks after operation. The speciments were analyzed with radiography and lightmicroscopy. Results: Complete new bone formation was observed on the implant interface in HBO group,while incomplele new bone formation in non-HBO group. Conclusion :HBO can improve the process of ossteointegration of implant in NVBG.

关 键 词：高压氧 骨内牙植物 骨移植 骨整合 组织学 

分 类 号：R459.6[医药卫生—治疗学]