金多靶对单纯性肥胖大鼠的减肥效果及机制探讨  

Exploration of Weight-Reducing Effect of Kintop in Obese Rats and Its Mechanism

作　　者：陈愉[1] 曲晓义[1] 张国平[1] 金惠铭[1] 焦东海 

机构地区：[1]上海医科大学病理生理学教研室,上海200032 [2]上海市香山中医院及上海市中西医结合肥胖病医疗协作中心

出　　处：《中国中西医结合杂志》2000年第9期685-688,共4页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：上海市促进高新科技成果转化项目!(No.99- 0 2 55)

摘　　要：目的 :研究不同剂量金多靶对肥胖大鼠的减肥效果及机制。方法 :以单纯性肥胖大鼠的体重、Lee′s指数、腹腔脂肪细胞总量、脂肪细胞大小、脂肪细胞瘦素表达 (免疫组化 ,ABC法 )、血清瘦素 (放免法 )、血脂和血糖为指标 ,比较不同剂量金多靶灌服 1个月 (限制饮食 )的减肥效果。结果 :中等剂量 (每天4 0mg/ 10 0 g体重 )金多靶灌服 1个月后大鼠减肥疗效较好。减肥同时血胆固醇及血糖有不同程度降低。减肥有效时脂肪细胞瘦素表达减弱 ,血清瘦素水平明显升高。结论 :金多靶 (每天 4 0mg/ 10 0 g体重 )灌服 1个月对单纯性肥胖大鼠有明显减肥疗效。金多靶减肥疗效可能与提高血清瘦素水平有关。金多靶有降低血胆固醇的作用 ,肥胖合并高血糖时适当加大金多靶剂量有降血糖效果。To investigate the weight-reducing effect of Kintop and its probable mechanism in obese rats. Methods: Body weight, Lee′s index, total weight of celiac fat tissue, adipocyte size, blood glucose, blood lipid, expression of leptin in adipocyte (by ABC method), level of serum leptin (by RIA) of obese rats were chosen as the indexes to compare the weight-reducing effect of different dosages of Kintop. The administration of Kintop lasted 1 month. Results: Good effect could be obtained by administration of medium dose Kintop (40 mg/100g body weight per day) in simple obese rats. At the same time of reducing body weight, blood cholesterol and sugar levels also decreased in a certain degree. The adipocyte leptin expression reduced and serum leptin elevated in those rats with body weight reduced effectively by Kintop. Conclusion: Medium dose of Kintop administration for 1 month shows evident weight-reducing effect in simple obese rats, the effect might be related to raising the serum leptin level. Kintop also has the effect in lowering blood cholesterol level, and it could lower the blood sugar in obesity complicated with hyperglycemia by increasing the dosage appropriately.

关 键 词：金多靶 肥胖 瘦素 减肥效果 

分 类 号：R285[医药卫生—中药学]