二丙酸倍氯米松干粉剂治疗晚发老年哮喘的临床观察  

Clinical study on the efficacy of beclomethasone dipropionate dry powder in the treatment of late onset asthma

作　　者：戴元荣[1] 颜静[1] 徐永安[1] 翁海霞[1] 赵爱娇[1] 

机构地区：[1]浙江省温州医学院附属第二医院呼吸科,325027

出　　处：《中华老年医学杂志》2000年第4期251-253,共3页Chinese Journal of Geriatrics

摘　　要：目的　观察吸入类固醇二丙酸倍氯米松 (BDP)干粉剂对晚发老年哮喘 (LOA)的疗效。　方法　将 2 2例LOA患者与 2 3例非老年哮喘患者进行对比研究 ,观察吸入 β2 受体激动剂沙丁胺醇干粉剂后 1秒钟用力呼气容积 (FEV1)的变化以及吸入BDP干粉剂后FEV1及其占预计值百分比(FEV1% )、早晚最大呼气流速 (PEFR)及其日内变异率等变化。　结果　两组患者在吸入沙丁胺醇干粉剂后FEV1均明显增高 (P <0 0 1) ,但非老年组FEV1升高较LOA更明显 (P <0 0 1)。在BDP干粉剂吸入 1周和 4周时 ,两组FEV1、FEV1%和PEFR均明显增高 (P <0 0 1) ,PEFR日内变异率明显下降 (P<0 0 1)。于治疗 1周时两组间FEV1%差异无显著性。　结论　BDP干粉剂能有效控制LOA。Objective To study the efficacy of inhaling beclomethasone dipropionate (BDP) dry powder for the treatment of late onset asthma(LOA). Methods Twenty two patients with LOA vs 23 non aged patients with asthma were comparatively studied using bronchodialator test. Forced expiratory volume in 1 second (FEV 1), peak expiratory flow rate (PEFR) in the early morning and the late afternoon, and diurnal variations in PEFR were measured before and after treatment. Results FEV 1 was significantly improved in both groups after inhaling salbutamol dry powder (P<0 01); however, the improvement in FEV 1 was significantly lower in LOA than that in the group of non aged patients with asthma(P<0 01). The FEV 1, FEV 1% and PEFR were significantly improved, the diurnal variation of PEFR was also significantly decreased in both groups after the treatment (P<0 01). It was showed that there was no significant difference in FEV 1% between two groups after 1 week treatment. Conclusions BDP dry powder inhalation is a highly effective therapy for the LOA patients.

关 键 词：晚发老年哮喘 药物疗法 二丙酸倍氯米松 干粉剂 

分 类 号：R562.25[医药卫生—呼吸系统]