α-硫辛酸治疗糖尿病神经病变对患者总症状评分的影响  

Effect of alpha-lipoic acid on TSS in patients with diabetic peripheral neuropathy

作　　者：冯英[1] 张佼佼[1] 刘春燕[1] 

机构地区：[1]天津泰达医院内二科,天津市300457

出　　处：《临床药物治疗杂志》2013年第4期30-33,共4页Clinical Medication Journal

摘　　要：目的:评价α-硫辛酸治疗2型糖尿病周围神经病变的有效性。方法:将2011年至2012年我院收治2型糖尿病周围神经病变患者共64例随机分为试验组(n=32)和对照组(n=32),其中试验组使用α-硫辛酸治疗,对照组使用谷胱甘肽治疗,治疗前后对其进行TSS。结果:试验组患者应用α-硫辛酸治疗后,TSS较治疗前改善4.37分(P<0.01),且未见明显不良反应。结论:α-硫辛酸相对于谷胱甘肽可明显改善2型糖尿病患者周围神经病变的症状,且无明显不良反应。Objective： To evaluate the effect of alpha-lipoic acid on diabetic peripheral neuropathy. Methods： A lot of 64 diabetic peripheral neuropathy patients collected from 2011 to 2012 in our hospital were assigned to alpha-lipoic acid （n=32, experiment group） or glutathione（n=32, control group）, for 14 days. The primary outcome measure was the change from baseline of the TSS, including stabbing pain, burning pain, paresthesia, and asleep numbness of the feet. Results： After use of alpha-lipoic acid, the TSS decreased significantly by 4.37 points, as compared with that at the baseline（P0.01）. TSS was more significantly decreased in the experiment group than in the control group （P0.05）. No adverse reactions occurred in both groups. Conclusions： As compared with glutathione, ALA could improved neuropathic symptoms effectively with no adverse reactions.

关 键 词：Α-硫辛酸 2型糖尿病 周围神经病变 TSS 

分 类 号：R587.2[医药卫生—内分泌] R969.4[医药卫生—内科学]