SiC管中微波辅助芳烃钌（Ⅱ）化合物[（η^6-C6H6）Ru（H2iiP）Cl]Cl的合成  

Microwave-assisted Synthesis of Arene Ru （ Ⅱ ） Complex [（η^6-C6H6）Ru（H2iiP）Cl]Cl in SiC Vessel

作　　者：吴琼[1] 梅文杰[1,2] 吴韦黎[1] 陈燕华[1] 曾玲莉[1] 郑文杰[2] 

机构地区：[1]广东药学院药科学院,广州510006 [2]暨南大学化学系,广州510632

出　　处：《高等学校化学学报》2013年第8期1863-1867,共5页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:20771044;21071062);广州市科技计划项目(批准号:2013J4100072);广东药学院大学生课外科技立项资助

摘　　要：使用SiC管为反应容器,在微波辐射条件下以[(η6-C6H6)RuCl2]2为原料与2-(吲哚基)咪唑[4,5-f]-[1,10]菲啰啉(H2iiP)反应,制得芳烃钌(Ⅱ)化合物[(η6-C6H6)Ru(H2iiP)Cl]Cl(1),并对其进行了表征.采用正交实验法确定反应的最佳合成条件为:投料比n([(η6-C6H6)RuCl2]2)∶n(H2iiP)=1∶2.2,反应温度90℃,微波辐射时间30 min.该反应的平均产率达到96.0%,反应产率的相对标准偏差(RSD)为1.28%,说明微波辐射条件下,在SiC管中能够高产率地制备芳烃钌化合物,并且反应具有良好的重现性.进一步采用MTT方法研究发现,芳烃钌(Ⅱ)化合物1能够选择性抑制MCF-7乳腺癌的生长.Arene Ru（Ⅱ） complex [（η^6-C6H6）Ru（H2iiP）Cl]Cl（1） was synthesized using [（η^6-C6H6）·5RuCl2]2 and 2-indole-3-imidazole[4,5-f][1,10] phenanthroline（H2iiP） as raw material under microwave irradiation. The target compound was characterized by means of elemental analysis, ESI-MS, IR and NMR. The best craft condition determined by orthogonal test is that reactant molar ratio of 1.0： 2.2, the reaction tempe-rature of 90℃ and the microwave irradiation time of 30 min. Then the average yield of 96.0% and RSD of 1.28% confirmed that microwave-assisted synthesis of arene Ru（Ⅱ） complex in SiC vessel gives a good stability and reiteration. The antitumor activity of arene Ru（Ⅱ） complex 1 was determined by MTT assay and the results showed that complex 1 could selectively inhibit the growth of MCF-7, indicating its potential utility in chemotherapy.

关 键 词：2-(吲哚基)咪唑[4 5-f][1 10]菲啰啉 芳烃钌(Ⅱ)化合物 SiC管 微波辅助合成 抗肿瘤 

分 类 号：O626.23[理学—有机化学]