丙泊酚复合瑞芬太尼用于无痛人流的临床观察  

Clinical Observation of Propofol Compound Remifentailuesed for Painless Abortions Surger

作　　者：刘波涛[1] 佟瑞芝[1] 郭志荣[2] 

机构地区：[1]首都医科大学燕京医学院附属北京房山良乡医院麻醉科,北京102401 [2]首都医科大学附属北京友谊医院麻醉科,北京100050

出　　处：《中国药学杂志》2013年第14期1213-1214,共2页Chinese Pharmaceutical Journal

摘　　要：目的比较不同靶浓度的丙泊酚复合瑞芬太尼用于无痛人流手术的疗效,以探讨丙泊酚复合瑞芬太尼靶控输注用于无痛人工流产手术的最佳靶浓度。方法对我院120例ASAI-II级择期行无痛人流手术的患者,随机分为3组,丙泊酚分别以2,3,4μg·mL-1的靶浓度复合瑞芬太尼靶控输注,比较3组患者各个时段的血液动力学变化,以及体动情况、出室时间等。结果 3组患者均能完成手术,2μg·mL-1组在扩宫和胎芽吸出时平均动脉压、心率升高较明显,体动发生率较高;4μg·mL-1组呼吸暂停例数、出室时间明显高于其他2组。结论应用靶浓度为3μg·mL-1丙泊酚复合靶浓度3μg·mL-1的瑞芬太尼组患者,术中平均动脉压、心率较平稳,呼吸暂停例数较少,出室时间较快,是一种适合无痛人流手术的较为理想的麻醉血浆靶控浓度。ObjectiveTo compare the efficacies of different target concentrations of propofol combinded with remifentanil for painless induced abortions, thus to explore the best target concentrations. Methods One hundred and twenty ASAI-Ⅱ patients receiving elective painless induced abortions between May 2011 and October 2011 were randomly divided into three groups. The target concentrations of propofol were 2, 3, and 4 μg·mL-1, respectively. The hemodynamic changes and body movements at different time and the time of leaving operating room in the three groups were compared. Results The patients in the three groups all finished operations. The MAPs and HRs when dilating uterine and aspirating embryo bud were significantly increased, and the incidence of body movements was the highest in the 2 μg·mL-1 group; the number of apnea cases and the time of leaving operation room in the 4 μg·mL-1 group were significantly higher than the other two groups. Conclusion When using propofol at target concentration of 3 μg·mL-1 combined with remifentanil at target concentration of 3 μg·mL-1 for painless induced abortions, the patients had stable perioperative MAP and HR, less apnea cases, and shorter time of leaving operation room. So these are the ideal target plasma concentrations for controlled anesthesia for painless induced abortions.

关 键 词：丙泊酚 瑞芬太尼 血浆靶控浓度 无痛人工流产 

分 类 号：R969[医药卫生—药理学]