通过Michael加成反应和氧化环化反应合成多取代缺电子环丁烷  

Synthesis of Polysubstituted Electron-Deficient Cyclobutane via Michael Addition and Oxidative Cyclization

作　　者：王广银[1] 吕绪良[1] 翁枭迪[1] 汤雪峰[2] 荣先辉[2] 

机构地区：[1]解放军理工大学电磁环境效应与光电工程重点实验室,南京210007 [2]解放军理工大学科研部,南京210007

出　　处：《有机化学》2013年第7期1532-1535,共4页Chinese Journal of Organic Chemistry

摘　　要：从简单易得的原料出发实现了多取代缺电子环丁烷的合成.该合成方法的关键反应是Michael加成反应和氧化环化反应.得到了目标产物的单晶结构,并且提出了可能的氧化环化反应机理.An efficient synthetic method to polysubstituted electron-deficient cyclobutane from simple starting materials was developed. The key reactions were a Michael addition and an iodine（Ⅲ）-mediated oxidative cyclization. The structure of product was confirmed by its single-crystal diffraction analysis. A tentative pathway for the oxidative cyclization was pro- posed.

关 键 词：环丁烷 MICHAEL加成 氧化环化 

分 类 号：O624.11[理学—有机化学]