吡啶-4-甲酰胺噁二唑化合物的合成及性质研究  

Synthesis and Properties of Pyridine-4-carboxamide1,3,4-oxadiazoles

作　　者：郑娟[1] 陈雨[2] 吴孔丽[1] 冉春玲[1] 徐琰[1] 宋毛平[1] 

机构地区：[1]郑州大学化学与分子工程学院,郑州450001 [2]郑州大学基础医学院,郑州450001

出　　处：《有机化学》2013年第7期1536-1539,共4页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.21171149)资助项目~~

摘　　要：以4-吡啶甲酸、芳香醛为原料,经缩合、氧化成环和酰化等反应,合成了4个未见文献报道的吡啶甲酰胺噁二唑类化合物,通过红外、核磁共振和元素分析对化合物的结构进行了表征.研究了这4个化合物的荧光性质和生物活性;荧光测试结果表明Cu2+可以使此系列化合物的荧光猝灭,Zn2+可以增强此系列化合物2-(吡啶-4-甲酰胺基)-5-对甲氧基苯基-1,3,4-噁二唑(2b)的荧光;生物活性测试结果表明这4个化合物对所测的5种病原菌都具有较好的杀菌活性,其中2-(吡啶-4-甲酰胺基)-5-对甲基苯基-1,3,4-噁二唑(2d)对小麦赤霉病菌的抑制活性可达到100%.Four new 2,5-disubstituted 1,3,4-oxadiazole derivative N-（5-aromatic-l,3,4-oxadiazol-2-yl）picolinamides 2a^2d were obtained by condensation, oxidization and acylation reactions, with isonicotinic acid and single substituted aromatic aldehydes as raw materials. These compounds were characterized by IR, 1H NMR and elemental analysis. Fluorescence test results indicated that Cu2＋ could make this series compounds fluorescence quenching, and Zn2~could only enhance the fluorescence intensity of N-[5-（4-methoxyphenyl）-l,3,4-oxadiazol-2-yl]isonicotinamide （2b）. Furthermore, those compounds all showed good fungicidal activity against the tested bacteria, and among them, N-（5-p-tolyl-l,3,4-oxadiazol-2- yl）isonicotinamide （2d） against Gibberella zeae was reached 100%.

关 键 词：1 3 4-噁二唑 荧光性质 生物活性 

分 类 号：O626[理学—有机化学]