Lucidone和Methyl Lucidone的简洁合成  

Concise Synthesis of Lucidone and Methyl Lucidone

作　　者：刘武[1] 肖粉粉[1] 胡向东[1] 

机构地区：[1]西北大学化学与材料科学学院教育部合成与天然功能分子重点实验室,西安710069

出　　处：《有机化学》2013年第7期1587-1590,共4页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.21002078)资助项目~~

摘　　要：报道了lucidone和methyl lucidone的简洁合成,其关键步骤为方酸二甲酯的还原/重排"一锅"反应和单甲氧基环丁烯二酮的达森/扩环反应.Lucidone的合成经过两步反应以46%的总收率实现.Methyl lucidone的合成经过三步反应以43%的总收率完成.The concise synthesis of lucidone and methyl lucidone is reported. The key steps include the one-pot reduc- tion/rearrangement of dimethyl squarate and the Darzens/ring expansion of the monomethoxyl cyclobutenedione. The synthe- sis of lucidone was finished in two steps and 46% total yield. And the synthesis of methyl lucidone had been reached in three steps and 43% overall yield.

关 键 词：lucidone methyllucidone 环丁烯二酮 达森扩环 简洁合成 

分 类 号：TQ460.1[化学工程—制药化工] R284[医药卫生—中药学]