头孢曲松氯化消毒转化产物鉴定及机理研究  

Transformation of ceftriaxone in chlorination process: Products identification and transformation pathways

作　　者：李立平[1] 魏东斌[1] 杜宇国[1] 

机构地区：[1]环境化学与生态毒理学国家重点实验室,中国科学院生态环境研究中心,北京100085

出　　处：《环境化学》2013年第7期1328-1334,共7页Environmental Chemistry

基　　金：国家自然科学基金项目(21077123,20877090,50938004)资助

摘　　要：以头孢曲松为目标化合物,探索其在氯消毒处理中的转化机理.结果显示头孢曲松在氯化处理中主要发生两种反应,一种为氧化反应,另一种为氯化反应.头孢曲松分子中的硫醚官能团经氧化生成亚砜产物,消毒剂中的氯原子与噻唑环中的4-C原子发生亲电取代反应生成氯代产物.更为重要的是,本研究还探讨了低浓度头孢曲松在环境水体基质中的氯化转化特征,结果表明,本文所推测的反应机理在含头孢曲松的实际环境水样的氯化处理中同样发生.Ceftriaxone was targeted to explore its transformation pathways in chlorination process. The results demonstrated that two reactions occurred during ceftriaxone chlorination, one was oxidation of sulfur atom in thioether to form sulfoxide products, and the other was electrophilic substitution by chlorine atom on 4-carbon atom with large negative charge in thiazole ring of ceftriaxone. In addition, we simulated the chlorination process of trace level ceftriaxone in ambient water matrix. It was found that the p pathways of ceftriaxone in ultrapure water matrix occured in the ambient water matrix.

关 键 词：头孢曲松 氯化 消毒副产物 转化机理 

分 类 号：X703[环境科学与工程—环境工程]