多肽PrP106-126对小脑颗粒神经元凋亡相关基因表达的影响  

Effects of Peptides PrP106-126 on Cerebellar Granule Neuron Apoptosis-related Genes Expression

作　　者：童双[1] 吴新涛[1] 黄志强[1] 于梦[1] 刘荣昌[1] 王衡[1] 宁章勇[1] 

机构地区：[1]华南农业大学兽医学院兽医病理教研室,广东广州510642

出　　处：《中国畜牧兽医》2013年第7期34-38,共5页China Animal Husbandry & Veterinary Medicine

基　　金：广东省自然科学基金项目(7300744)

摘　　要：试验旨在研究多肽PrP106-126对小脑颗粒神经元凋亡相关基因表达的影响。本研究利用多肽PrP106-126作用于小脑颗粒神经细胞,对该多肽影响小脑颗粒神经细胞凋亡基因的表达进行了检测。结果表明:bax、caspase-3和myc基因在PrP106-126多肽作用后表达显著增加,而bcl-2基因表达明显下降,进一步验证了bax、caspase-3和myc基因具有诱导凋亡作用,而bcl-2基因则具有抑制凋亡作用。The study focused on the effects of peptides PrP106-126 on cerebellar granule neuron apoptosis-related genes ex- pression. In this study, we detected expression changes of the cerebellar granule neuronal apoptosis gene affected by the pep- tide PrP106-126. The results showed that the expression of bax, caspase-3 and myc genes increased significantly after stimula- ted. On the contrary, the bcl-2 gene expression decreased significantly, which further confirmed that bax, caspase-3 and myc genes could induce cell apoptosis and bcl-2 gene could inhibit cell apoptosis.

关 键 词：传染性海绵体脑病 朊蛋白 小脑颗粒神经细胞 细胞凋亡 

分 类 号：S852.659.7[农业科学—基础兽医学]