热休克蛋白在肝细胞癌形成、增殖、复发、转移及抗肿瘤免疫中的作用研究  

Research on the role of heat shock proteins in carcinogenesis,.proliferation,.recurrence,metastasis and anti-tumor immune responses of hepatocellular carcinoma

作　　者：吴嘉仪[1] 李高鹏[1] 罗葆明[1] 

机构地区：[1]中山大学孙逸仙纪念医院超声科,广州510120

出　　处：《岭南现代临床外科》2013年第4期367-369,F0003,共4页Lingnan Modern Clinics in Surgery

基　　金：国家自然青年科学基金(编号:81201810);广东省自然科学基金博士启动项目(编号:S2012040007819);教育部博士点基金(编号:20120171110080)

摘　　要：热休克蛋白(heat shock proteins,HSPs)是一类结构高度保守的蛋白质,主要参与蛋白的转运、折叠、维持蛋白质自身稳定及免疫应答。大量研究表明,HSPs中多个成员如HSP27、HSP70及HSP90,在肝细胞癌(hepatocellular carcinoma,HCC)中呈过表达。本文就HSPs在肝细胞癌的形成、增殖、复发、转移及抗肿瘤免疫的作用进行综述。Heat shock proteins（HSPs） are a class of proteins with extremely conservation,which involve in many vital chaperoning processes such as protein folding,transporting,stabilization and antigenic presentation.Some of the HSPs,such as HSP27,HSP70,and HSP90,are frequently overexpressed in hepatocellular carcinoma（HCC）.This review summarizes the role of HSPs in carcinogenesis,proliferation,recurrence,metastasis and anti-tumor immune responses of HCC.

关 键 词：癌 肝细胞 热休克蛋白类 

分 类 号：R602[医药卫生—外科学]