格列本脲致低血糖反应的文献分析  

Literature Analysis of the Low Blood Sugar Reactions Caused By Glibenclamide

作　　者：郭美华[1] 邱晓红 马满玲[1] 胡宝荣[1] 马妍妍[1] 刘世萍[1] 

机构地区：[1]哈尔滨医科大学附属第一医院药学部,黑龙江哈尔滨150001 [2]哈尔滨市公安医院药剂科,黑龙江哈尔滨150027

出　　处：《中国药物警戒》2013年第7期424-426,431,共4页Chinese Journal of Pharmacovigilance

基　　金："胰岛素药物流行病学的研究";紫禁城国际药师论坛科研课题项目;编号:CJP-1101-25

摘　　要：目的探讨格列本脲致低血糖反应发生的情况并分析相关因素,为临床合理用药提供参考。方法对格列本脲致的742例低血糖反应文献进行分类统计与分析。结果男女比例为1.1:1,老年人占88.0%,39.6%的病例存在不合理用药行为,14.6%单独用药,43.9%联合用药,临床表现以低血糖昏迷为主(62.7%),93.5%病例治愈,48例转归不良(死亡41例)。结论格列本脲可引起较为严重的低血糖反应,甚至可致死亡,使用时须慎重考虑年龄、用法用量等相关因素,做到合理用药,减少低血糖反应的发生。ObjectiveTo analyze the cases of low blood sugar reactions caused by glibenclamide and identify the relevant factors,provide a reference for the clinical use of drugs.Methods 742 cases of glibenclamide-induced low blood sugar reactions were statistically analyzed.Results Male to Female ratio was 1.1：1,88.0% of the cases are the elderly,39.6% of them had non-standard situation of drug use,14.6% of them used single drug,43.9% of them had the combined use of drugs.Clinical types of the cases were mainly hypoglycemic coma（62.7%）,93.5% of them were cured,48 cases showed adverse outcome（death in 41 cases）.Conclusion Glibenclamide can cause relatively severe low blood sugar reactions,and even lead to death.When use,the age,usage,dosage and other factors must be carefully considered,so as to medicate rationally and then reduce the incidence of hypoglycemia.

关 键 词：格列本脲 药源性低血糖 合理用药 

分 类 号：R977.15[医药卫生—药品] R994.11[医药卫生—药学]