细胞骨架与机械应力在机械通气相关性肺损伤中的病理生理作用  

The effect of cytoskeleton and mechanotransduction in the pathophysiology of ventilator4nduced lung injury

作　　者：方梦可[1] 张宗泽[1] 陈畅[1] 

机构地区：[1]武汉大学附属中南医院麻醉科,430071

出　　处：《国际麻醉学与复苏杂志》2013年第8期732-736,共5页International Journal of Anesthesiology and Resuscitation

基　　金：国家自然科学基金（81000318）;武汉青年科技晨光计划项目（201271031425）

摘　　要：背景机械通气相关性肺损伤（ventilator induced lung injury，VILI）是机械通气治疗中常见的严重并发症，过度牵拉引起的细胞机械应力是由细胞骨架以及细胞蜘胞间和细胞-细胞外基质的相互作用调节完成。目的探讨细胞骨架在VILI中的病理生理机制，丰富和完善VILI理论。内容描述了机械通气刺激被转化为细胞内的生理信号，从而诱导细胞活化、增加肺血管通透性导致肺损伤。对细胞骨架与机械应力在VILI中的病理生理作用进行详尽的阐述。趋向关于细胞骨架及其相关结构在VILI的病理生理变化中作用的体外研究已广泛开展，但体内VILI模型较少，需进一步的研究。Background Although mechanical ventilation is an important therapy, it can result in complications. Cellular meehanotransduetion of the overstretehing stimulus is mediated by means of the eytoskeleton and its cell-cell and cell-extracellular matrix interactions. Objective The aim of this review is to summarize the effect of cytoskeleton and mechanotransduction in the pathophysiology of ventilator-induced lung injury （VILI）. Content This review describe the mechanical stimulus of ventilation is translated into an intracellular biochemical signal, inducing endothelial activation, pulmonary vascular permeability and lung injury. The review has been focused on the cytoskeleton and mechanotransduction in the pathophysiology of VILI. Trend Although the cytoskeleton plays a fundamental role in the pathogenesis of VILI, there have been few in vivo studies about alterations in the cytoskeleton and in cytoskeleton-assoeiated proteins during this pathological process. More research on VILI is still worth exploring to meet clinical patients need.

关 键 词：呼吸 人工 细胞骨架 细胞黏附分子 机械应力 

分 类 号：R563.8[医药卫生—呼吸系统]