尿毒症患者维持性血液透析对氧化应激及免疫功能的影响  

The oxidative stress and immune function`s effect of uremia patients with maintenance hemodialysis

作　　者：孙续禄[1] 

机构地区：[1]四川省达州职业技术学院,635000

出　　处：《中国医疗前沿》2013年第12期56-56,20,共2页China Healthcare Innovation

摘　　要：目的研究维持性血液透析的尿毒症患者氧化应激以及免疫功能的变化,为尿毒症透析治疗提供指导依据。方法选取于本院血液透析室规律透析的尿毒症患者、年龄相仿的健康人各30例,分别对其进行T淋巴细胞群、NK细胞、免疫球蛋白等免疫指标以及CRP、IL-6、MDA、Hcy等氧化应激指标的测定(尿毒症患者分别测透析前后各指标)并比较分析。结果尿毒症透析后较透析前CRP升高,IL-6、MDA、Hcy降低,免疫球蛋白、T淋巴细胞亚群、NK细胞升高,差异有统计学意义(P<0.05)。结论维持性血液透析会加重尿毒症患者的氧化应激状态,充分透析有助于改善免疫功能状态。Objective To study the The oxidative stress and immune function＇s effect of uremia patients with maintenance hemodialysis, aiming to provide guidance for uremic dialysis treatment. Method Select 30 dialysis patients doing hemodialysis in our hospital and 30 cases of healthy of the same age. Check their immune indexes such as T lymphocytes, NK ceils and Ig, oxidative stress indicators such as MDA, CRP,IL-6, and Hey（uremic patients were measured before and after hemodialysis）. Compare and analysis them. Results Before dialysis has a higher CRP and lower IL-6, MDA, Hcy, higher T lymphocyte subsets, Ig and NK cells, P〈0.05, the difference has statistically significant. Conclusion Maintenance hemodialysis will worsen the oxidative stress state of the patients with uremia, adequate dialysis can help improve the immune function.

关 键 词：尿毒症 血液透析 氧化应激 免疫功能 影响 

分 类 号：R692.5[医药卫生—泌尿科学]