NT-proBNP检测对充血性心力衰竭预后的评估  

Prognostic value of serum NT-proBNP concentration in patients with congestive heart failure

作　　者：李建华 

机构地区：[1]广东省广州市从化龙潭医院,广东广州510945

出　　处：《心血管病防治知识（学术版）》2013年第7期35-37,共3页Prevention and Treatment of Cardiovascular Disease

基　　金：广州市医药卫生科技项目基金:201102A214015

摘　　要：目的探讨N端脑钠肽前体(NT-proBNP)浓度变化对充血性心力衰竭患者预后的评估。方法回顾分析诊断为充血性心力衰竭患者80例,在入院当天、治疗72小时和出院时检测血NT-proBNP,观察住院期间和出院后6个月内心脏不良事件发生率及病死率。结果充血性心力衰竭患者80例中4例死亡,76例经过治疗出院。所有患者的NT-proBNP的增高与心功能分级的增高成正比,Ⅳ级组的NT-proBNP值显著高于Ⅱ级组、Ⅲ级组的检测值(P<0.05);治疗后NT-proBNP水平较治疗前明显下降(P<0.01)。出院随访6个月,发生心脏事件者入院时血NT-proBNP浓度明显高于未发生心脏事件者(P<0.05)。结论 NT-proBNP的浓度的变化能预测充血性心力衰竭患者的预后,血NT-proBNP浓度增高,提示近期预后差。Objective To investigate the prognostic value of serum N-terminal pro-brain natriuretic peptide （NT-proBNP） concentration in patients with congestive heart failure （CHF）. Methods A retrospective analysis was performed in 80 patients diagnosed with CHF. Their serum NT-proBNP concentrations were measured on the day of admission, after 72 hours of treatment, and at discharge, and the incidence rates of cardiovascular events and fatality rates during hospital stay and within 6 months after discharge were calculated. Results Of the 80 CHF patients, 4 died, and 76 were discharged after treatment. Among all cases, the increase in serum NT-proBNP concentration was proportional to that in cardiac functional grading; the serum NT-proBNP concentration was significantly higher in grade IV group than in grade II and III groups （P 〈0.05）. The patients had significantly decreased serum NT-proBNP levels after treatment （P 〈0.01）. The 6-month follow-up showed that the patients who developed cardiovascular events had a significantly higher serum NT-proBNP concentration on the day of admission than those who did not （P 〈0.05）. Conclusion The change in serum NT-proBNP concentration is valuable in predicting the outcome of CHF patients; increased serum NT-proBNP concentration suggests poor short-term prognosis.

关 键 词：N端脑钠肽前体 充血性心力衰竭 预后 

分 类 号：R541.6[医药卫生—心血管疾病]