225例药物性肝损害临床分析  

Clinical Analysis of 225 Cases of Drug Hepatic Damage

作　　者：孟珺[1] 曾康健 何光明[1] 

机构地区：[1]北京大学深圳医院,广东深圳518036

出　　处：《今日药学》2013年第6期373-374,377,共3页Pharmacy Today

基　　金：广东省医院药学研究基金(编号:2012A07)

摘　　要：目的分析药物性肝损害的病因、临床特点及预后,并评价治疗效果,以提高对药物性肝损害的认识,促进临床合理用药。方法回顾性分析本院2005～2011年间225例药物性肝损害住院患者的基本情况、用药史及临床特点,探讨其发生的可能机制。结果引起药物性肝损害前4位药物分别是抗肿瘤化疗药(35.1%),中草药(19.2%),抗感染药(10.3%),心血管药(10.3%)等,主要临床表现为腹胀、腹痛、纳差、黄疸。肝损害以肝细胞损伤型最为常见。结论引起药物性肝损害的药物种类繁多,临床表现无特异性,因此临床用药要严格把握用药指征,进而做到预防药物性肝损害的发生。Objective To analyze the etiology, clinical characteristics and evaluate the efficiency of the treatment, in order to improve the understanding prognosis of drug hepatic damage, and to of the drug hepatic damage, and so as to promote the clinical rational drug application. Methods The basic situation, the medical history and clinical characteristics of 225 hospitalized patients in 2005-2011 with hepatic damage were retrospectively analyzed, and the possible mechanism was discussed. Results The top 4 drugs that cause drug hepatic damage were antitumor drugs （35.1%）, Chinese herbal medicine （ 19.2% ）, anti-infective （ 10.3% ） drugs, main clinical manifestations were as follow： abdominal distension, abdominal pain, cardiovascular drugs （10.3%）. The anorexia, jaundice. Liver cell damage was the most common type of liver damage. Conclusion There are many kinds of drug that can cause hepatic damage, and there were no specific clinical manifestations. Therefore the clinical application of drugs should strictly be accordance with its indication, to prevent the occurrence of drug hepatic damage.

关 键 词：药物性肝损害 数据库 临床资料 

分 类 号：R97[医药卫生—药品]