超微粉碎对蒙药文冠木中总黄酮的体外溶出度影响  

Study on Dissolution Rate of General Flavonoides in Xanthoceras Sorbifolia Bung by Technique of Superfine Grinding

作　　者：鞠爱华[1] 周凯 张静 蔡丽娟[1] 宋萍萍[1] 王承楠 

机构地区：[1]内蒙古医科大学药学院,呼和浩特010059 [2]内蒙古食品药品检验所,呼和浩特010059

出　　处：《中国现代应用药学》2013年第7期745-747,共3页Chinese Journal of Modern Applied Pharmacy

基　　金：国家十二五科技支撑项目(2012BAI28B01)

摘　　要：目的采用紫外分光光度法对文冠木普通粉和超微粉中主要有效成分总黄酮的溶出度进行比较。方法采用桨状搅拌法,紫外分光光度法在500 nm处测定文冠木普通粉与超微粉总黄酮的体外溶出度。结果文冠木超微粉中总黄酮在单位时间内的溶出速率明显高于普通粉,且溶出量较普通粉提高了约20%。结论微粉化技术能明显提高文冠木中主要有效成分总黄酮的体外溶出度。OBJECTIVE To establish a UV method for comparing the exoteric dissolution of general flavonoides between the ultra-micro and traditional powder of Xanthoceras sorbifolia Bung.METHODS The dissolution of general flavonoides from the ultra-micro and traditional powder of Xanthoceras sorbifolia Bung was determined by UV at a detection wavelength of 500 nm.RESULTS The dissolution rate of ultra-micro powder of Xanthoceras sorbifolia Bung was increased obviously than common powder.The dissolution amount raised 20% in ultra-micro powder of Xanthoceras sorbifolia Bung.CONCLUSION Superfine grinding can promote the dissolution of general flavonoides in Xanthoceras sorbifolia Bung.

关 键 词：蒙药文冠木 超微粉 紫外分光光度法 总黄酮 溶出度 

分 类 号：R943[医药卫生—药剂学]