GC测定藿香正气滴丸中百秋李醇的含量  

Quantitative Determination of Patchouli Alcohol in Huoxiang Zhengqi Dripping Pill By GC

作　　者：阚红玉[1] 尹俏[1] 刘彦莉[1] 孙玉侠[1] 曹凤兰[1] 

机构地区：[1]天士力制药集团股份有限公司,天津300410

出　　处：《中国现代应用药学》2013年第7期762-764,共3页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的建立藿香正气滴丸中百秋李醇的含量测定方法。方法采用气相色谱法测定处方中广藿香油的含量。色谱条件：固定相以5%苯基95%二甲基聚硅氧烷为填料的毛细管柱,检测器为FID氢火焰离子化检测器;进样口温度：280℃;检测器温度：280℃;柱温：165℃,程序升温,载气：氮气;分流进样;分流比：5∶1;进样量：1 L。结果百秋李醇在0.030 0~0.961 0μg（r=0.999 9）内峰面积与其进样量线性关系良好;百秋李醇平均回收率为101.1%,RSD为1.45%;样品溶液在24 h内稳定。结论该方法快捷、准确,重复性好,能够用于藿香正气滴丸的质量控制。OBJECTIVE To determine the content of Patchouli alcohol in Huoxiang Zhengqi Dripping Pill by GC.METHODS The GC separation was performed on capillary gas chromatographic column;FID flame ionization detector;carrier gas is nitrogen;temperature setting： sampling input temperature 280 ℃;column temperature 165 ℃,temperature programming process;detector temperature 280 ℃;split ratio： 5 ∶ 1;sample size： 1 μL.RESULTS In the GC experiments of precision,reproducibility and stability,the samples could be separated entirely.For patchouli alcohol,the linear range was 0.030 0 0.961 0 μg（r=0.999 9）,the average recoveries were 101.1% with RSD=1.45% and it was stable in 24 h.CONCLUSION The method was sensitive,simple,accurate and reproducible,can be used to control the quality of Huoxiang Zhengqi Dripping Pill.

关 键 词：藿香正气滴丸 气相色谱法 百秋李醇 

分 类 号：R284.1[医药卫生—中药学] R917.101[医药卫生—中医学]