利巴韦林雾化吸入治疗毛细支气管炎的临床观察  

Clinical research of ribavirin nebulisation in treatment of bronchiolitis

作　　者：宁建英[1] 刘莹[1] 陈波[1] 

机构地区：[1]石河子大学医学院第一附属医院儿科,新疆石河子832008

出　　处：《临床和实验医学杂志》2013年第13期1010-1011,1014,共3页Journal of Clinical and Experimental Medicine

基　　金：石河子大学科学技术研究发展计划项目;项目编号:ZRKXYB-LH02

摘　　要：目的观察利巴韦林雾化吸入治疗毛细支气管炎的临床疗效及安全性。方法符合毛细支气管炎诊断患儿80例,依据临床表现分为重症40例,轻症40例,将其随机分为治疗组与对照组(两组重症、轻症各20例),均采用综合治疗。治疗组予以利巴韦林配制成浓度20 g/L的雾化溶液氧泵雾化吸入,4次/d,连用3～7 d。观察各组临床症状、体征缓解情况,住院天数及血象、肝肾功能变化情况。结果重症患儿治疗组的临床症状、体征缓解时间及平均住院天数均较对照组改善明显,两组比较差异有显著性(P<0.05);轻症患儿治疗组的临床症状、体征缓解时间及平均住院天数与对照组差异无显著性(P>0.05);治疗后患儿外周血白细胞数、血红蛋白含量均在正常范围,无肝、肾功能异常。结论利巴韦林雾化吸入治疗毛细支气管炎,对重症患儿能改善临床症状,促进肺部啰音消散,缩短住院天数;对轻症患儿疗效不确切;利巴韦林雾化吸入治疗对血液系统及肝肾功能无明显副作用。Objective To observe the curative effect and security of ribavirin nebulisation in treatment of capillary bronchitis.Methods 80 cases of children with diagnostic criteria of bronchiolitis were included into this study,randomly divided into treatment group and control group according to mild case and severe case by clinical manifestation.Both of the groups were treated with comprehensive therapy.Treatment groups were assisted with atomization treatment of Ribavirin with concentration of 20 g/l and frequency of 4 times a day,repeated 3～7 days.The situations of symptoms and signs released,hospital days,functions of liver and renal change were observed and analyzed.Results The clinical symptoms and signs of children with severe disease,average hospitalization days in treatment group were obviously improved compared with the control group.The statistics had significant difference（P〈0.05）.The total effective rate of children with mild disease in treatment group and control group were not statistically significant difference（P〈0.05）.Peripheral white blood cells,hemoglobins and functions of liver and renal after treatment were in the normal range.Conclusion It is a good way to treat severe children bronchiolitis with ribavirin atomization.This therapeutic method can improve clinical symptoms,promote bellows rales disappearing,shorten average hospital days.However,the curative effect is not sure to mild cases.No obvious side effect of hematological system and functions of liver and renal was reported up to now.

关 键 词：毛细支气管炎 利巴韦林 雾化吸入 

分 类 号：R725.6[医药卫生—儿科]