大鼠黄褐斑动物模型的建立  

Building the Mouse Models of Chloasma

作　　者：蒲春霞[1] 何海蓉[1] 

机构地区：[1]成都大学医护学院,四川成都610106

出　　处：《河北科技师范学院学报》2013年第2期66-69,共4页Journal of Hebei Normal University of Science & Technology

摘　　要：为探索黄褐斑发病机理,建立黄褐斑的动物模型,选择20只雌性大鼠,肌肉注射黄体酮注射液1次/日,7.5 mg/kg,连续注射30 d。结果表明,黄体酮注射30 d后,大鼠皮肤和肝脏的酪氨酸、MDA含量升高,SOD含量降低,皮肤病理形态学观察黑色素沉着面积扩大、着色加深。大鼠注射黄体酮可作为研究黄褐斑的动物模型。To investigate the mechanism of the chloasma, the mouse models were built by injecting Progester- one. The MDA, beta-parahydroxy-phenylpropionic acid in tissues, Melanoma ceils of skin of the mice in pre- vention group was significantly creased, SOD increased and Blood rheology decreased than those in normal group. It suggested that the animal model of chloasma was successfully established.

关 键 词：黄褐斑 动物模型 大鼠 黄体酮注射 

分 类 号：R758.42[医药卫生—皮肤病学与性病学]