Prophylaxis of the Autoimmune Diseases  

作　　者：Duncan D. Adams John G. Knight Alan Ebringer 

机构地区：[1]Faculty of Medicine, University of Otago, Dunedin, New Zealand [2]Faculty of Commerce, University of Otago, Dunedin, New Zealand [3]King's College, University of London, United Kingdom

出　　处：《Journal of US-China Medical Science》2013年第1期30-36,共7页美中医学（英文版）

摘　　要：Pasteur＇s correct Germ Theory of Disease led to discovery of the Immunity System that exists for defense against diseases caused by bacteria or virus infections. In order to cope with the huge diversity of microbial infections, the immunity system needs a flexibility of immune response. This is provided by use of semi-random somatic gene mutations in lymphocytes, the cells that recognize invading bacteria and viruses. Burnet realized that this flexibility leads to development of the Forbidden Clones that cause the autoimmune diseases by accidentally being reactive with a host antigen instead of a microbial one. Ebringer has recently discovered the microbial triggers of rheumatoid arthritis and ankylosing spondylitis and has determined the amino acid sequences of the antigens on them that trigger the related autoimmune diseases. This has explained how histocompatibility antigens can predispose to autoimmune diseases. The Salk and Sabin anterior poliomyelitis vaccines have prevented the polio epidemic leg paralyses. We postulate that these paralyses were rare autoimmune complications of virtually universal poliovirus infection. As autoimmune diseases are triggered by microbial infections, we suggest that the triggering bacteria or viruses be sought, so that prophylaxis of the autoimmune diseases can be achieved by vaccination against their triggering microbes.

关 键 词：Forbidden Clone theory H Gene theory microbial triggers of autoimmune diseases poliomyelitis vaccines prophylaxisof poliomyelitis paralyses prophylaxis of autoimmune diseases. 

分 类 号：Q2[生物学—细胞生物学] S858.28[农业科学—临床兽医学]