布托啡诺联合异丙酚用于无痛肠镜70例  

Clinical effect of use of Bhutto butorphanol combined with propofol in painless colonoscopy:An analysis of 70 cases

作　　者：赵峰[1] 庞留成[1] 赵彦芬[1] 张振华[1] 毛轲[1] 

机构地区：[1]河南省中医院麻醉科,河南省郑州市450002

出　　处：《世界华人消化杂志》2013年第20期1996-1999,共4页World Chinese Journal of Digestology

摘　　要：目的:探讨布托啡诺复合异丙酚在无痛肠镜检查中的应用.方法:使用随机数字表法将140例进行无痛肠镜检查的患者分为对照组和观察组各70例,所有患者均首先应用1.5-2.0mg/kg异丙酚至意识消失,然后对照组患者给予缓慢静脉滴注瑞芬太尼1-g/kg;观察组静脉注入布托啡诺15-g/kg;检查中连续检测患者的生命体征和肢体反应,比较两组患者和麻醉前、术中、术后的平均动脉压(mean arterial pressure,MAP)、静脉血氧饱和度(blood oxygen saturation,SPO2)和心率(heart rate,HR)的变化,记录手术时间、术后苏醒时间、VAS评分及术后呼吸障碍、腹痛、头晕、呕吐等不良反应的情况.结果:两组患者MAP、SPO2和HR术后的变化与术前无统计学差异,术后均有下降,其中观察组HR由术前88次/min降至86次/min,较对照组(88-82次/min)更为稳定.观察组的检查时间和术后清醒时间均少于对照组,其中观察组术后清醒时间与对照组相比,差异具有显著统计学意义(7.5min±1.5min vs12.5min±3.5min,P<0.01),观察组VAS疼痛评分均<4分,但观察组疼痛感更低,与对照组相比差异具有显著统计学意义(2.57±0.83vs3.32±1.25,P<0.01).观察组不良反应情况发生少于对照组.结论:布托啡诺联合异丙酚进行无痛肠镜检查时镇痛效果良好,患者术后清醒时间短,不良反应少,值得临床推广.AIM：To explore the application of Bhutto butorphanol combined with propofol in painless colonoscopy.METHODS：One hundred and forty patients treated by painless colonoscopy were randomly and equally divided into either a control group or an observation group.The control group was intravenously injected with remifentanil 1 μg/kg and propofol 2 mg/kg,while the observation group was intravenously injected with Bhutto butorphanol 15 ？g/kg and propofol 2 mg/kg.Analgesic effects were compared between the two groups before anesthesia,intraoperatively and postoperatively.Changes in mean arterial pressure（MAP）,venous oxygen saturation（SPO2） and heart rate（HR） were monitored,and postoperative recovery time and adverse reactions such as respiratory disorder,abdominal pain,dizziness,and vomiting were recorded.RESULTS：MAP,SPO2 and HR showed no significant differences in the two groups between before and after operation（observation group：88 times/min vs 86 times/min;control group：88 times/min vs 82 times/min）.Postoperative awake time was significantly shorter in the observation group than in the control group（7.5 min ± 1.5 min,12.5 min ± 3.5 min,P 0.01）.VAS pain score was signif icantly lower in the observation group than in the control group（2.57 ± 0.83,3.32 ± 1.25,P 0.01）.The incidence of adverse reactions was also lower in the observation group than in the control group.CONCLUSION：The use of Bhutto butorphanol combined with propofol in painless colonoscopy is associated with good analgesic effect,short postoperative recovery time and few adverse reactions.

关 键 词：布托啡诺 异丙酚 无痛肠镜 SPO2 

分 类 号：R614[医药卫生—麻醉学]