正常肾脏3．0T磁共振扩散张量成像研究  

Diffusion Tensor Imaging of Normal Human Kidney on 3.0 T

作　　者：范文骏[1] 沈文[1] 龙淼淼[1] 黄黎香[1] 李琼[1] 

机构地区：[1]天津医科大学第一中心临床学院放射科,天津300192

出　　处：《临床放射学杂志》2013年第8期1123-1127,共5页Journal of Clinical Radiology

摘　　要：目的评估肾脏扩散张量成像(DTI)检查的可行性,观察正常肾脏3.0 T MR DTI参数值特点及扩散张量示踪图表现。方法采用3.0 T MR成像系统,结合呼吸触发技术,对30名健康志愿者行双侧肾脏斜冠状面DTI检查,在6个非共线性方向施加扩散敏感梯度场,b值采用0、300 s/mm2,分别测量双肾皮髓质各异性分数(FA)值及表观扩散系数(ADC)值,采用配对样本t检验比较双肾皮质间、双肾髓质间及每侧肾皮髓质间的FA值、ADC值,同时重建双肾扩散张量示踪图,观察其图像特征。结果 (1)双肾皮质间、双肾髓质间FA值及ADC值差异均无统计学意义(P>0.05);(2)肾脏皮质FA值(0.32±0.04)明显低于髓质(0.70±0.05),皮质ADC值[(2.83±0.20)×10-3mm2/s]明显高于髓质[(2.50±0.18)×10-3mm2/s],差异均有统计学意义(t=-43.87,P<0.001;t=11.14,P<0.001);(3)扩散张量示踪图显示肾髓质内由肾门指向皮髓质交界的放射状分布的纤维束样结构。结论采用3.0 T MR结合呼吸触发技术可以获得良好的肾脏DTI图像;肾脏DTI是描述肾脏皮髓质扩散特征并直观显示肾髓质微观结构的有效检查技术。Objective To evaluate the feasibility of diffusion tensor imaging （DTI） in normal kidney, and to observe the characteristics of DTI parameters and diffusion tensor tractography （DIT） in normal human kidney using 3.0T magnetic resonance imaging （MRI） system. Methods DTI of the normal kidney of 30 healthy volunteers were obtained using 3.0T MRI scanners combined with respiration-triggered acquisition （ h-values 0 and 300s/ram2, diffusion direction of 6 ）. Frac- tional anisotropy（FA） and apparent diffusion coefficient （ADC） values of renal cortex and the medulla of bilateral kidney were measured and compared. Meanwhile, the DTF features of bilateral kidney were observed. Results The values of FA and ADC has no statistic difference between two side of kidney （ P 〉 0.05 ）. In all volunteers, FA values in the medulla （0.70 ±O. 05 ） were significantly higher than in the cortex （0.32 ± 0.04） （ t = - 43.87, P 〈 0.001 ） , whereas the ADC values in the cortex （2.83 ±0.20） x 10-3 mm2/s were higher than in the medulla （2.50 ± 0.18 ） x 10-3 mm2/s （t = 11.14 ,P 〈 0.001 ）. DTF images revealed a typical radial medullary microstructure. Conclusion DTI of kidneys can be obtained using 3.0 T MR scanners combined with respiration triggered acquisition. Renal DTI is an effective method to re- flect diffuse characteristics of both the cortex and the medulla, and to visually demonstrate microstructure of the medulla.

关 键 词：扩散张量成像 示踪图 各向异性分数 肾脏 

分 类 号：R445.2[医药卫生—影像医学与核医学]