天然免疫中重要的接头分子的研究进展  

Essential adaptors of innate immune signaling

作　　者：陈慧慧[1] 蒋争凡[1] 

机构地区：[1]北京大学生命科学学院,北京100871

出　　处：《科学通报》2013年第21期2021-2034,共14页Chinese Science Bulletin

基　　金：国家杰出青年科学基金(31025010)资助

摘　　要：天然免疫信号通路中的模式识别受体(pattern recognition receptor,PRR),可识别入侵机体的外来微生物及机体自身的一些内源性物质,将信号中转至细胞内重要的枢纽分子MyD88/TRIF/MAVS/STING/caspase-1等进行整合,继而激活相应的转录因子IRF3/IRF7/NF-B/AP-1及信号转导子和转录子STAT6,诱导下游靶基因,如Ⅰ型干扰素和炎症因子的表达,促进炎症小体的组装等.大多数细胞因子可进行旁分泌或自分泌并与其受体结合激活JAK-STAT信号通路,影响免疫细胞的活性、增殖与分化,进一步增强机体抵抗外界干扰的能力.本研究主要围绕天然免疫信号通路中几个重要的接头分子来展开对天然免疫信号级联网络的讨论.Microbial components and endogenous molecules released from damaged cells can stimulate germline-encoded pattern recognition receptors （PRRs） to transduce signals through the innate immune signaling network, consisting of the adaptor proteins MyD88/TRIF/ MAVS/STING/caspase-1. These integrated signals recruit specific transcription factors IRF3/IRFT/NF-r,B/AP-1 and signal transducer and activator of transcription 6 （STAT6） to induce the expression of type I interferons and inflammatory cytokines or the assembly of inflammasomes. Most cytokines with pleiotropic functions are secreted and mediate their effects by binding to specific receptors, thus activating signaling pathways including JAK-STAT, which induces the proliferation, differentiation and functional capacity of immune ceils. This review focuses on several critical adaptors of innate immune signaling cascades and the recent progress in understanding their molecular mechanisms.

关 键 词：天然免疫 感染 细胞信号 转导 

分 类 号：Q504[生物学—生物化学]